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dc.contributor.authorVoss, Oliver H
dc.contributor.authorRahman, M Sayeedur
dc.date.accessioned2021-04-21T13:50:40Z
dc.date.available2021-04-21T13:50:40Z
dc.date.issued2021-03-11
dc.identifier.urihttp://hdl.handle.net/10713/15445
dc.description.abstractBacterial infection is a highly complex biological process involving a dynamic interaction between the invading microorganism and the host. Specifically, intracellular pathogens seize control over the host cellular processes including membrane dynamics, actin cytoskeleton, phosphoinositide metabolism, intracellular trafficking and immune defense mechanisms to promote their host colonization. To accomplish such challenging tasks, virulent bacteria deploy unique species-specific secreted effectors to evade and/or subvert cellular defense surveillance mechanisms to establish a replication niche. However, despite superficially similar infection strategies, diverse Rickettsia species utilize different effector repertoires to promote host colonization. This review will discuss our current understandings on how different Rickettsia species deploy their effector arsenal to manipulate host cellular processes to promote their intracytosolic life within the mammalian host. © The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.en_US
dc.description.urihttps://doi.org/10.1093/femspd/ftab015en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofPathogens and Diseaseen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.en_US
dc.subjectRickettsia-host interactionen_US
dc.subjectbacterial adherence and engulfmenten_US
dc.subjectbacterial effector moleculesen_US
dc.subjecthost defensesen_US
dc.subjectintracellular traffickingen_US
dc.subjectphagosomal escapeen_US
dc.subjectphosphoinositide metabolismen_US
dc.subjectspotted fever groupen_US
dc.subjecttransition groupen_US
dc.subjecttyphus groupen_US
dc.titleRickettsia-host interaction: strategies of intracytosolic host colonizationen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/femspd/ftab015
dc.identifier.pmid33705517
dc.source.volume79
dc.source.issue4
dc.source.countryUnited States
dc.source.countryUnited States


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