Rickettsia-host interaction: strategies of intracytosolic host colonization
JournalPathogens and Disease
PublisherOxford University Press
MetadataShow full item record
AbstractBacterial infection is a highly complex biological process involving a dynamic interaction between the invading microorganism and the host. Specifically, intracellular pathogens seize control over the host cellular processes including membrane dynamics, actin cytoskeleton, phosphoinositide metabolism, intracellular trafficking and immune defense mechanisms to promote their host colonization. To accomplish such challenging tasks, virulent bacteria deploy unique species-specific secreted effectors to evade and/or subvert cellular defense surveillance mechanisms to establish a replication niche. However, despite superficially similar infection strategies, diverse Rickettsia species utilize different effector repertoires to promote host colonization. This review will discuss our current understandings on how different Rickettsia species deploy their effector arsenal to manipulate host cellular processes to promote their intracytosolic life within the mammalian host. © The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.
Rights/Terms© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.
bacterial adherence and engulfment
bacterial effector molecules
spotted fever group
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15445
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