The impact of primary tumor sidedness on survival in early-onset colorectal cancer by stage: A National Veterans Affairs retrospective analysis
Author
Azar, IbrahimAl Masalmeh, Nada
Esfandiarifard, Saghi
Virk, Gurjiwan
Kiwan, Wissam
Shields, Anthony Frank
Mehdi, Syed
Philip, Philip A
Date
2021-04-02Journal
Cancer MedicinePublisher
Wiley-BlackwellType
Article
Metadata
Show full item recordAbstract
Background: The incidence of early-onset colorectal cancer (EOCRC) is rising. Left-sided colorectal cancer (LCC) is associated with better survival compared to right-sided colon cancer (RCC) in metastatic disease. NCCN guidelines recommend the addition of EGFR inhibitors to KRAS/NRAS WT metastatic CRC originating from the left only. Whether laterality impacts survival in locoregional disease and EOCRC is of interest. Methods: 65,940 CRC cases from the National VA Cancer Cube Registry (2001-2015) were studied. EOCRC (2096 cases) was defined as CRC diagnosed at <50 years. Using ICD codes, RCC was defined from the cecum to the hepatic flexure (C18.0-C18.3), and LCC from the splenic flexure to the rectum (C18.5-18.7; C19 and C20). Results: EOCRC is more likely to originate from the left side (66.65% LCC in EOCRC vs. 58.77% in CRC). Overall, LCC has better 5-year Overall Survival (OS) than RCC in stages I (61.67% vs. 58.01%) and III (46.1% vs. 42.1%) and better 1-year OS in stage IV (57.79% vs. 49.49%). Stage II RCC has better 5-year OS than LCC (53.39% vs. 49.28%). In EOCRC, there is no statistically significant difference between LCC and RCC in stages I-III. Stage IV EOCRC patients with LCC and RCC have a 1-year OS of 73.23% and 59.84%, respectively. Conclusion: In EOCRC, LCC is associated with better OS than RCC only stage IV. In the overall population, LCC is associated with better OS in all stages except stage II. The better prognosis of stage II RCC might be due to the high incidence of mismatch repair deficient tumors in this subpopulation.Rights/Terms
© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.Keyword
colon cancercolorectal cancer
early-onset colorectal cancer
laterality
left-sided colon cancer
primary tumor sidedness
right-sided colon cancer
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http://hdl.handle.net/10713/15436ae974a485f413a2113503eed53cd6c53
10.1002/cam4.3757
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