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dc.contributor.authorPiao, Wenji
dc.contributor.authorKasinath, Vivek
dc.contributor.authorSaxena, Vikas
dc.contributor.authorLakhan, Ram
dc.contributor.authorIyyathurai, Jegan
dc.contributor.authorBromberg, Jonathan S
dc.date.accessioned2021-04-14T12:30:14Z
dc.date.available2021-04-14T12:30:14Z
dc.date.issued2021-03-29
dc.identifier.urihttp://hdl.handle.net/10713/15402
dc.description.abstractThe pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival.en_US
dc.description.urihttps://doi.org/10.3390/cells10040747en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCellsen_US
dc.subjectTreg migrationen_US
dc.subjectlymphatic endothelial cellsen_US
dc.subjectlymphotoxinen_US
dc.subjectlymphotoxin β receptor signalingen_US
dc.subjectnon-canonical nuclear factor κB pathwayen_US
dc.titleLTβR Signaling Controls Lymphatic Migration of Immune Cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cells10040747
dc.identifier.pmid33805271
dc.source.volume10
dc.source.issue4
dc.source.countrySwitzerland


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