Show simple item record

dc.contributor.authorWright, Jamie
dc.contributor.authorNguyen, Annie
dc.contributor.authorD'Souza, Nandika
dc.contributor.authorForbess, Joseph M.
dc.contributor.authorNugent, Alan
dc.contributor.authorReddy, Surendranath R. Veeramen_US
dc.contributor.authorJaquiss, Roberten_US
dc.contributor.authorWelch, Tré Raymonden_US
dc.date.accessioned2021-04-14T12:22:36Z
dc.date.available2021-04-14T12:22:36Z
dc.date.issued2021-03-19
dc.identifier.urihttp://hdl.handle.net/10713/15401
dc.description.abstractIntravascular stents for pediatric patients that degrade without inhibiting vessel growth remain a clinical challenge. Here, poly(L-lactide) fibers (DH-BDS) at two thicknesses, 250 µm and 300 µm, were assembled into large, pediatric-sized stents (Ø10 - Ø20 mm). Fibers were characterized mechanically and thermally, then stent mechanical properties were compared to metal controls, while mass loss and degradation kinetics modeling estimated total stent degradation time. Thicker fibers displayed lower stiffness (1969 ± 44 vs 2126 ± 37 MPa) and yield stress (117 ± 12 vs 137 ± 5 MPa) than thinner counterparts, but exhibited similar fail strength (478 ± 28 vs 476 ± 16 MPa) at higher strains (47 ± 2 vs 44 ± 2%). Stents all exhibited crystallinity between 51.3 – 54.4% and fiber glass transition temperatures of 88.6 ± 0.5°C and 84.6 ± 0.5°C were well above physiological ranges. Radial strength (0.31 ± 0.01 - 0.34 ± 0.02 N/mm) in thinner stents was similar to metal stents (0.24 – 0.41 N/mm) up to Ø14 mm with no foreshortening and thicker coils granted comparable radial strength (0.32 ± 0.02 - 0.34 ± 0.02 N/mm) in stents larger than Ø14 mm. Both 10 mm (1.17 ± 0.02 % and 0.86 ± 0.1 %) and 12 mm (1.1 ± 0.03% and 0.89 ± 0.1%) stents exhibited minimal weight loss over one year. Degradation kinetics models predicted full stent degradation within 2.8 - 4.5 years depending on thickness. DH-BDS exhibiting hoop strength similar to metal stents and demonstrating minimal degradation and strength loss over the first year before completely disappearing within 3 to 4.5 years show promise as a pediatric interventional alternative to current strategies.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.description.urihttps://doi.org/10.1016/j.mtla.2021.101078en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMaterialiaen_US
dc.subjectDegradation kineticsen_US
dc.subjectGlass transition temperatureen_US
dc.subjectPoly(L-lactide)en_US
dc.subjectTensile strengthen_US
dc.titleBioresorbable stent to manage congenital heart defects in childrenen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.mtla.2021.101078
dc.source.volume16


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record