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dc.contributor.authorPhe, K.
dc.contributor.authorHeil, E.L.
dc.contributor.authorTam, V.H.
dc.date.accessioned2021-04-12T20:02:40Z
dc.date.available2021-04-12T20:02:40Z
dc.date.issued2020-07-20
dc.identifier.urihttp://hdl.handle.net/10713/15365
dc.description.abstractCritically ill patients with sepsis or septic shock are at an increased risk of death. Early and aggressive interventions are essential for improving clinical outcomes. There are a number of therapeutic and practical challenges in the management of antimicrobials in patients with sepsis. These include the timely selection and administration of appropriate antimicrobials, significant physiological alterations that can influence antimicrobial pharmacokinetics, and significant interpatient variability of antimicrobial concentrations using standard dosing approaches. Understanding the impact of these factors on the probability of attaining pharmacokinetic-pharmacodynamic target goals is essential to guide optimal therapy. Using rapid diagnostic technology could facilitate timely selection of antimicrobials, and therapeutic drug monitoring would provide a more individualized dosing approach. Using an interdisciplinary sepsis team would also be beneficial in coordinating efforts to overcome the challenges encountered during this critical period to ensure optimal care. Copyright The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.en_US
dc.description.sponsorshipFinancial support. This work is supported in part by the National Institutes of Health (grant R01AI140287-01 to V. H. T.).en_US
dc.description.urihttps://doi.org/10.1093/INFDIS/JIAA118en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofJournal of Infectious Diseases
dc.subjectAntibioticsen_US
dc.subjectDosingen_US
dc.subjectMonitoringen_US
dc.subjectPharmacokineticsen_US
dc.subjectPhysiological alterationsen_US
dc.subjectTreatmenten_US
dc.titleOptimizing pharmacokinetics-pharmacodynamics of antimicrobial management in patients with sepsis: A reviewen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/INFDIS/JIAA118
dc.identifier.pmid32691832


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