Optimizing pharmacokinetics-pharmacodynamics of antimicrobial management in patients with sepsis: A review
Date
2020-07-20Journal
Journal of Infectious DiseasesPublisher
Oxford University PressType
Article
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Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and aggressive interventions are essential for improving clinical outcomes. There are a number of therapeutic and practical challenges in the management of antimicrobials in patients with sepsis. These include the timely selection and administration of appropriate antimicrobials, significant physiological alterations that can influence antimicrobial pharmacokinetics, and significant interpatient variability of antimicrobial concentrations using standard dosing approaches. Understanding the impact of these factors on the probability of attaining pharmacokinetic-pharmacodynamic target goals is essential to guide optimal therapy. Using rapid diagnostic technology could facilitate timely selection of antimicrobials, and therapeutic drug monitoring would provide a more individualized dosing approach. Using an interdisciplinary sepsis team would also be beneficial in coordinating efforts to overcome the challenges encountered during this critical period to ensure optimal care. Copyright The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.Sponsors
Financial support. This work is supported in part by the National Institutes of Health (grant R01AI140287-01 to V. H. T.).Identifier to cite or link to this item
http://hdl.handle.net/10713/15365ae974a485f413a2113503eed53cd6c53
10.1093/INFDIS/JIAA118
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