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    Optimizing pharmacokinetics-pharmacodynamics of antimicrobial management in patients with sepsis: A review

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    Author
    Phe, K.
    Heil, E.L.
    Tam, V.H.
    Date
    2020-07-20
    Journal
    Journal of Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/INFDIS/JIAA118
    Abstract
    Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and aggressive interventions are essential for improving clinical outcomes. There are a number of therapeutic and practical challenges in the management of antimicrobials in patients with sepsis. These include the timely selection and administration of appropriate antimicrobials, significant physiological alterations that can influence antimicrobial pharmacokinetics, and significant interpatient variability of antimicrobial concentrations using standard dosing approaches. Understanding the impact of these factors on the probability of attaining pharmacokinetic-pharmacodynamic target goals is essential to guide optimal therapy. Using rapid diagnostic technology could facilitate timely selection of antimicrobials, and therapeutic drug monitoring would provide a more individualized dosing approach. Using an interdisciplinary sepsis team would also be beneficial in coordinating efforts to overcome the challenges encountered during this critical period to ensure optimal care. Copyright The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
    Sponsors
    Financial support. This work is supported in part by the National Institutes of Health (grant R01AI140287-01 to V. H. T.).
    Keyword
    Antibiotics
    Dosing
    Monitoring
    Pharmacokinetics
    Physiological alterations
    Treatment
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15365
    ae974a485f413a2113503eed53cd6c53
    10.1093/INFDIS/JIAA118
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