Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance
JournalJournal of Infectious Diseases
PublisherOxford University Press
MetadataShow full item record
AbstractPatients with sepsis present across a spectrum of infection sites and severity of illnesses requiring complex decision making at the bedside as to when prompt antibiotics are indicated and which regimen is warranted. Many hemodynamically stable patients with sepsis and low acuity of illness may benefit from further work up before initiating therapy, whereas patients with septic shock warrant emergent broad-spectrum antibiotics. The precise empiric regimen is determined by assessing patient and epidemiological risk factors, likely source of infection based on presenting signs and symptoms, and severity of illness. Hospitals should implement quality improvement measures to aid in the rapid and accurate diagnosis of septic patients and to ensure antibiotics are given to patients in an expedited fashion after antibiotic order. Copyright 2020 Oxford University Press. All rights reserved.
SponsorsFinancial support. This study was funded by the Intramural Research Program of the National Institutes of Health Clinical Center.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15364
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