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    Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance

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    Author
    Strich, J.R.
    Heil, E.L.
    Masur, H.
    Date
    2020-07-21
    Journal
    Journal of Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/INFDIS/JIAA221
    Abstract
    Patients with sepsis present across a spectrum of infection sites and severity of illnesses requiring complex decision making at the bedside as to when prompt antibiotics are indicated and which regimen is warranted. Many hemodynamically stable patients with sepsis and low acuity of illness may benefit from further work up before initiating therapy, whereas patients with septic shock warrant emergent broad-spectrum antibiotics. The precise empiric regimen is determined by assessing patient and epidemiological risk factors, likely source of infection based on presenting signs and symptoms, and severity of illness. Hospitals should implement quality improvement measures to aid in the rapid and accurate diagnosis of septic patients and to ensure antibiotics are given to patients in an expedited fashion after antibiotic order. Copyright 2020 Oxford University Press. All rights reserved.
    Sponsors
    Financial support. This study was funded by the Intramural Research Program of the National Institutes of Health Clinical Center.
    Keyword
    Antimicrobial resistance
    Empiric antibiotics
    Sepsis
    Septic shock
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15364
    ae974a485f413a2113503eed53cd6c53
    10.1093/INFDIS/JIAA221
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