Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies
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2020-10-09Journal
Trends in Molecular MedicinePublisher
Elsevier LtdType
Article
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Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where treatment varies by patient and disease activity. Strong preclinical results and clinical correlates have motivated development of many drugs, but many of these have failed to achieve efficacy in clinical trials. FDA approval of belimumab in 2011 was the first successful SLE drug in nearly six decades. In this article, we review insights into the molecular and clinical heterogeneity of SLE from transcriptomics studies and detail their potential impact on drug development and clinical practices. We critically examine the pipeline of SLE drugs, including past failures and their associated lessons and current promising approaches. Finally, we identify opportunities for integrating these findings and drug development with new multidisciplinary advances to enhance future SLE treatment. Copyright 2020 Elsevier LtdKeyword
patient heterogeneitypersonalized medicine
systemic lupus erythematosus
systems immunology
therapies
transcriptomics
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http://hdl.handle.net/10713/15332ae974a485f413a2113503eed53cd6c53
10.1016/j.molmed.2020.09.009
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