• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Allen, M.E.
    Rus, V.
    Szeto, G.L.
    Date
    2020-10-09
    Journal
    Trends in Molecular Medicine
    Publisher
    Elsevier Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.molmed.2020.09.009
    Abstract
    Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where treatment varies by patient and disease activity. Strong preclinical results and clinical correlates have motivated development of many drugs, but many of these have failed to achieve efficacy in clinical trials. FDA approval of belimumab in 2011 was the first successful SLE drug in nearly six decades. In this article, we review insights into the molecular and clinical heterogeneity of SLE from transcriptomics studies and detail their potential impact on drug development and clinical practices. We critically examine the pipeline of SLE drugs, including past failures and their associated lessons and current promising approaches. Finally, we identify opportunities for integrating these findings and drug development with new multidisciplinary advances to enhance future SLE treatment. Copyright 2020 Elsevier Ltd
    Keyword
    patient heterogeneity
    personalized medicine
    systemic lupus erythematosus
    systems immunology
    therapies
    transcriptomics
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15332
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molmed.2020.09.009
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • The pathogenesis of systemic lupus erythematosus: Harnessing big data to understand the molecular basis of lupus.
    • Authors: Catalina MD, Owen KA, Labonte AC, Grammer AC, Lipsky PE
    • Issue date: 2020 Jun
    • From old concerns to new advances and personalized medicine in lupus: The end of the tunnel is approaching.
    • Authors: Doria A, Gershwin ME, Selmi C
    • Issue date: 2016 Nov
    • Biologics in SLE: the current status.
    • Authors: Rajadhyaksha AG, Mehra S, Nadkar MY
    • Issue date: 2013 Apr
    • Unmet Needs in the Pathogenesis and Treatment of Systemic Lupus Erythematosus.
    • Authors: Bakshi J, Segura BT, Wincup C, Rahman A
    • Issue date: 2018 Dec
    • Dendritic cells as key players in systemic lupus erythematosus.
    • Authors: Kaewraemruaen C, Ritprajak P, Hirankarn N
    • Issue date: 2020 Dec
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.