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dc.contributor.authorTiano, Susan L.
dc.date.accessioned2012-04-23T18:14:00Z
dc.date.available2012-04-23T18:14:00Z
dc.date.issued1995
dc.identifier.urihttp://hdl.handle.net/10713/1528
dc.descriptionUniversity of Maryland, Baltimore. Pharmaceutical Sciences. Ph.D. 1995en_US
dc.description.abstractThere are currently no USP performance standards for nebulizers and their associated respiratory solutions. This research sought to establish reliable methodologies for comparing total aerosolized output (TO), output rate (OR) and fine droplet fraction (FDF) between an air-jet and an ultrasonic nebulizer. The nebulized output of an aqueous 0.08% w/v fluorescein solution was collected in a total output collection device and four inertial samplers over 0.5, 2 and 5 minutes. Increases in airflow rate to the air-jet nebulizer resulted in significant increases in output rate and variability. However, no practical increases in fine droplet fraction for the air-jet nebulizer were observed. The determination of fine droplet fraction from an ultrasonic nebulizer was found to be prone to sampler overloading. Results among the impactors showed similar trends, but the data was not interchangeable. Using the validated methods established for characterizing a respiratory solution, a model suspension containing 0.1% w/v fluorescein (to estimate droplet deposition) and known quantities of 1, 3 and 6 mum latex spheres (representing insoluble drug particles) was aerosolized from an air-jet and an ultrasonic nebulizer to determine if differences in the aerosolization mechanism affected droplet and sphere deposition. Nebulized output was collected in a modified Andersen impactor. Samples were analyzed spectrophotometrically and by a Coulter Counter to estimate droplet and sphere deposition, respectively. Theoretical mathematical predictions were compared to experimental findings. Significant differences between nebulizers were observed. In the ultrasonic nebulizer, 99% of the spheres were not aerosolized, which the model did not predict. However, the results more closely followed the model for the air-jet nebulizer, since a substantial fraction of the spheres appeared in the aerosolized output. Any attempt to regulate nebulizer performance standards should consider that dissolved drug or droplet deposition patterns do not necessarily reflect those of undissolved drug particles. This research highlighted several justifications for reliably evaluating nebulizer output characteristics. The presented methods provide a rational basis to evaluate performance of nebulizers and their associated respiratory solutions or suspensions.en_US
dc.language.isoen_USen_US
dc.subjectChemistry, Pharmaceuticalen_US
dc.subjectHealth Sciences, Pharmacyen_US
dc.subjectHealth Sciences, Public Healthen_US
dc.titleFunctionality testing used to rationally assess performance of a model respiratory solution or suspension in a nebulizeren_US
dc.typedissertationen_US
dc.contributor.advisorDalby, Richard N.
dc.identifier.ispublishedYes
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