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dc.contributor.authorMeng, X.
dc.contributor.authorMukherjee, D.
dc.contributor.authorKao, J.P.Y.
dc.contributor.authorKanold, P.O.
dc.date.accessioned2021-04-12T16:48:46Z
dc.date.available2021-04-12T16:48:46Z
dc.date.issued2021-02-12
dc.identifier.urihttp://hdl.handle.net/10713/15224
dc.description.abstractCortical function can be shaped by sensory experience during a critical period. The onset of the critical period is thought to coincide with the onset of thalamocortical transmission to the thalamo-recipient layer 4 (L4). In early development, subplate neurons (SPNs), and not L4 neurons, are the first targets of thalamic afferents. SPNs are transiently involved in early development and are largely eliminated during development. Activation of L4 by thalamic afferents coincides with the opening of ear canal (~P11 in mice) and precedes the later critical period. Here, we show in mice that abolishing peripheral function or presenting sound stimuli even before P11 leads to bidirectionally altered functional connectivity of SPNs in auditory cortex. Thus, early sensory experience can sculpt subplate circuits before thalamocortical circuits to L4 are mature. Our results show that peripheral activity shapes cortical circuits in a sequential manner and from earlier ages than has been appreciated. Copyright Copyright 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.description.sponsorshipThis study was supported by NIH R01DC009607 (P.O.K.) and NIH R01GM056481 (J.P.Y.K.).en_US
dc.description.urihttps://doi.org/10.1126/sciadv.abc9155en_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.ispartofScience Advances
dc.subjectcortical circuitsen_US
dc.subjectsensory stimulien_US
dc.subjectsubplate neuronsen_US
dc.subject.meshAuditory Cortex--growth & developmenten_US
dc.subject.meshMiceen_US
dc.titleEarly peripheral activity alters nascent subplate circuits in the auditory cortexen_US
dc.typeArticleen_US
dc.identifier.doi10.1126/sciadv.abc9155
dc.identifier.pmid33579707


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