Early peripheral activity alters nascent subplate circuits in the auditory cortex
Date
2021-02-12Journal
Science AdvancesPublisher
American Association for the Advancement of ScienceType
Article
Metadata
Show full item recordAbstract
Cortical function can be shaped by sensory experience during a critical period. The onset of the critical period is thought to coincide with the onset of thalamocortical transmission to the thalamo-recipient layer 4 (L4). In early development, subplate neurons (SPNs), and not L4 neurons, are the first targets of thalamic afferents. SPNs are transiently involved in early development and are largely eliminated during development. Activation of L4 by thalamic afferents coincides with the opening of ear canal (~P11 in mice) and precedes the later critical period. Here, we show in mice that abolishing peripheral function or presenting sound stimuli even before P11 leads to bidirectionally altered functional connectivity of SPNs in auditory cortex. Thus, early sensory experience can sculpt subplate circuits before thalamocortical circuits to L4 are mature. Our results show that peripheral activity shapes cortical circuits in a sequential manner and from earlier ages than has been appreciated. Copyright Copyright 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Sponsors
This study was supported by NIH R01DC009607 (P.O.K.) and NIH R01GM056481 (J.P.Y.K.).Identifier to cite or link to this item
http://hdl.handle.net/10713/15224ae974a485f413a2113503eed53cd6c53
10.1126/sciadv.abc9155
Scopus Count
Collections
Related articles
- Subplate neurons are the first cortical neurons to respond to sensory stimuli.
- Authors: Wess JM, Isaiah A, Watkins PV, Kanold PO
- Issue date: 2017 Nov 21
- Earliest Experience of a Relatively Rare Sound But Not a Frequent Sound Causes Long-Term Changes in the Adult Auditory Cortex.
- Authors: Mehra M, Mukesh A, Bandyopadhyay S
- Issue date: 2022 Feb 23
- Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.
- Authors: Viswanathan S, Sheikh A, Looger LL, Kanold PO
- Issue date: 2017 Oct 1
- Differential signaling to subplate neurons by spatially specific silent synapses in developing auditory cortex.
- Authors: Meng X, Kao JP, Kanold PO
- Issue date: 2014 Jun 25
- Impaired Hearing and Altered Subplate Circuits During the First and Second Postnatal Weeks of Otoferlin-Deficient Mice.
- Authors: Mukherjee D, Meng X, Kao JPY, Kanold PO
- Issue date: 2021 Nov 24