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dc.contributor.authorAlipio, J.B.
dc.contributor.authorBrockett, A.T.
dc.contributor.authorFox, M.E.
dc.contributor.authorTennyson, S.S.
dc.contributor.authordeBettencourt, C.A.
dc.contributor.authorEl-Metwally, D.
dc.contributor.authorFrancis, N.A.
dc.contributor.authorKanold, P.O.
dc.contributor.authorLobo, M.K.
dc.contributor.authorRoesch, M.R.
dc.contributor.authorKeller, A.
dc.date.accessioned2021-04-12T16:48:43Z
dc.date.available2021-04-12T16:48:43Z
dc.date.issued2021-03-18
dc.identifier.urihttp://hdl.handle.net/10713/15203
dc.description.abstractOpioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits that result from perinatal opioid exposure. There are few preclinical models that accurately recapitulate human perinatal drug exposure and few focus on fentanyl, a potent synthetic opioid that is a leading driver of the opioid epidemic. To investigate the consequences of perinatal opioid exposure, we administered fentanyl to mouse dams in their drinking water throughout gestation and until litters were weaned at postnatal day (PD) 21. Fentanyl-exposed dams delivered smaller litters and had higher litter mortality rates compared with controls. Metrics of maternal care behavior were not affected by the treatment, nor were there differences in dams' weight or liquid consumption throughout gestation and 21 days postpartum. Twenty-four hours after weaning and drug cessation, perinatal fentanyl-exposed mice exhibited signs of spontaneous somatic withdrawal behavior and sex-specific weight fluctuations that normalized in adulthood. At adolescence (PD 35), they displayed elevated anxiety-like behaviors and decreased grooming, assayed in the elevated plus maze and sucrose splash tests. Finally, by adulthood (PD 55), they displayed impaired performance in a two-tone auditory discrimination task. Collectively, our findings suggest that perinatal fentanyl-exposed mice exhibit somatic withdrawal behavior and change into early adulthood reminiscent of humans born with NOWS. Copyright 2020 Society for the Study of Addictionen_US
dc.description.sponsorshipOlivia Uddin and Lace M. Riggs (Program in Neuroscience, University of Maryland School of Medicine) critically reviewed the content and provided revision.en_US
dc.description.urihttps://doi.org/10.1111/adb.12895en_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofAddiction Biology
dc.subjectC57BL/6en_US
dc.subjectdevelopmenten_US
dc.subjectneonatal abstinence syndromeen_US
dc.subjectopiatesen_US
dc.subjectpostnatalen_US
dc.subjectprenatalen_US
dc.titleEnduring consequences of perinatal fentanyl exposure in miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/adb.12895
dc.identifier.pmid32187805


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