Author
Alipio, J.B.Brockett, A.T.
Fox, M.E.
Tennyson, S.S.
deBettencourt, C.A.
El-Metwally, D.
Francis, N.A.
Kanold, P.O.
Lobo, M.K.
Roesch, M.R.
Keller, A.
Date
2021-03-18Journal
Addiction BiologyPublisher
Blackwell Publishing LtdType
Article
Metadata
Show full item recordAbstract
Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits that result from perinatal opioid exposure. There are few preclinical models that accurately recapitulate human perinatal drug exposure and few focus on fentanyl, a potent synthetic opioid that is a leading driver of the opioid epidemic. To investigate the consequences of perinatal opioid exposure, we administered fentanyl to mouse dams in their drinking water throughout gestation and until litters were weaned at postnatal day (PD) 21. Fentanyl-exposed dams delivered smaller litters and had higher litter mortality rates compared with controls. Metrics of maternal care behavior were not affected by the treatment, nor were there differences in dams' weight or liquid consumption throughout gestation and 21 days postpartum. Twenty-four hours after weaning and drug cessation, perinatal fentanyl-exposed mice exhibited signs of spontaneous somatic withdrawal behavior and sex-specific weight fluctuations that normalized in adulthood. At adolescence (PD 35), they displayed elevated anxiety-like behaviors and decreased grooming, assayed in the elevated plus maze and sucrose splash tests. Finally, by adulthood (PD 55), they displayed impaired performance in a two-tone auditory discrimination task. Collectively, our findings suggest that perinatal fentanyl-exposed mice exhibit somatic withdrawal behavior and change into early adulthood reminiscent of humans born with NOWS. Copyright 2020 Society for the Study of AddictionSponsors
Olivia Uddin and Lace M. Riggs (Program in Neuroscience, University of Maryland School of Medicine) critically reviewed the content and provided revision.Identifier to cite or link to this item
http://hdl.handle.net/10713/15203ae974a485f413a2113503eed53cd6c53
10.1111/adb.12895
Scopus Count
Collections
Related articles
- Perinatal Opioid Exposure Results in Persistent Hypoconnectivity of Excitatory Circuits and Reduced Activity Correlations in Mouse Primary Auditory Cortex.
- Authors: Xue B, Alipio JB, Kao JPY, Kanold PO
- Issue date: 2022 Apr 27
- Gestational buprenorphine exposure: Effects on pregnancy, development, neonatal opioid withdrawal syndrome, and behavior in a translational rodent model.
- Authors: Wallin CM, Bowen SE, Roberge CL, Richardson LM, Brummelte S
- Issue date: 2019 Dec 1
- Perinatal Fentanyl Exposure Leads to Long-Lasting Impairments in Somatosensory Circuit Function and Behavior.
- Authors: Alipio JB, Haga C, Fox ME, Arakawa K, Balaji R, Cramer N, Lobo MK, Keller A
- Issue date: 2021 Apr 14
- NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice.
- Authors: Marsman D
- Issue date: 1995 Apr
- Environmental Enrichment Mitigates the Long-Lasting Sequelae of Perinatal Fentanyl Exposure in Mice.
- Authors: Alipio JB, Riggs LM, Plank M, Keller A
- Issue date: 2022 Apr 27