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    Enduring consequences of perinatal fentanyl exposure in mice

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    Author
    Alipio, J.B.
    Brockett, A.T.
    Fox, M.E.
    Tennyson, S.S.
    deBettencourt, C.A.
    El-Metwally, D.
    Francis, N.A.
    Kanold, P.O.
    Lobo, M.K.
    Roesch, M.R.
    Keller, A.
    Show allShow less

    Date
    2021-03-18
    Journal
    Addiction Biology
    Publisher
    Blackwell Publishing Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1111/adb.12895
    Abstract
    Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits that result from perinatal opioid exposure. There are few preclinical models that accurately recapitulate human perinatal drug exposure and few focus on fentanyl, a potent synthetic opioid that is a leading driver of the opioid epidemic. To investigate the consequences of perinatal opioid exposure, we administered fentanyl to mouse dams in their drinking water throughout gestation and until litters were weaned at postnatal day (PD) 21. Fentanyl-exposed dams delivered smaller litters and had higher litter mortality rates compared with controls. Metrics of maternal care behavior were not affected by the treatment, nor were there differences in dams' weight or liquid consumption throughout gestation and 21 days postpartum. Twenty-four hours after weaning and drug cessation, perinatal fentanyl-exposed mice exhibited signs of spontaneous somatic withdrawal behavior and sex-specific weight fluctuations that normalized in adulthood. At adolescence (PD 35), they displayed elevated anxiety-like behaviors and decreased grooming, assayed in the elevated plus maze and sucrose splash tests. Finally, by adulthood (PD 55), they displayed impaired performance in a two-tone auditory discrimination task. Collectively, our findings suggest that perinatal fentanyl-exposed mice exhibit somatic withdrawal behavior and change into early adulthood reminiscent of humans born with NOWS. Copyright 2020 Society for the Study of Addiction
    Sponsors
    Olivia Uddin and Lace M. Riggs (Program in Neuroscience, University of Maryland School of Medicine) critically reviewed the content and provided revision.
    Keyword
    C57BL/6
    development
    neonatal abstinence syndrome
    opiates
    postnatal
    prenatal
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15203
    ae974a485f413a2113503eed53cd6c53
    10.1111/adb.12895
    Scopus Count
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