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dc.contributor.authorBhat, A.
dc.contributor.authorIrizar, H.
dc.contributor.authorThygesen, J.H.
dc.contributor.authorKuchenbaecker, K.
dc.contributor.authorPain, O.
dc.contributor.authorAdams, R.A.
dc.contributor.authorZartaloudi, E.
dc.contributor.authorAustin-Zimmerman, I.
dc.contributor.authorWang, B.
dc.contributor.authorMuir, R.
dc.contributor.authorSummerfelt, A.
dc.contributor.authorDu, X.M.
dc.contributor.authorBruce, H.
dc.contributor.authorO'Donnell, P.
dc.contributor.authorSrivastava, D.P.
dc.contributor.authorFriston, K.
dc.contributor.authorHong, L.E.
dc.contributor.authorHall, M.-H.
dc.contributor.authorBramon, E.
dc.contributor.authorHarju-Seppänen, J.
dc.date.accessioned2021-04-12T16:16:42Z
dc.date.available2021-04-12T16:16:42Z
dc.date.issued2021-03-16
dc.identifier.urihttp://hdl.handle.net/10713/15189
dc.description.abstractMismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. Here, we perform a transcriptome-wide association study of 728 individuals, which reveals 2 genes (FAM89A and ENGASE) whose expression in cortical tissues is associated with MMN. Enrichment analyses of neurodevelopmental expression signatures show that genes associated with MMN tend to be overexpressed in the frontal cortex during prenatal development but are significantly downregulated in adulthood. Endophenotype ranking value calculations comparing MMN and three other candidate psychosis endophenotypes (lateral ventricular volume and two auditory-verbal learning measures) find MMN to be considerably superior. These results yield promising insights into sensory processing in the cortex and endorse the notion of MMN as a psychosis endophenotype. Copyright 2021 The Author(s)Bhat et al. identify two genes, FAM89A and ENGASE, whose expression in cortical tissue is negatively associated with mismatch negativity (MMN), an electrophysiological measure of cortical responses to unexpected sensory stimuli. They find enrichment of neurotransmission-regulating genes in these associations and endorse MMN as an endophenotype for psychosis. Copyright 2021 The Author(s)en_US
dc.description.urihttps://doi.org/10.1016/j.celrep.2021.108868en_US
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofCell Reports
dc.subjectBayesian brainen_US
dc.subjectendophenotypeen_US
dc.subjectgene expressionen_US
dc.subjectmismatch negativityen_US
dc.subjectMMNen_US
dc.subjectneurodevelopmenten_US
dc.subjectprediction erroren_US
dc.subjectpsychosisen_US
dc.subjectschizophreniaen_US
dc.subjecttranscriptome-wide association studyen_US
dc.titleTranscriptome-wide association study reveals two genes that influence mismatch negativityen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.celrep.2021.108868
dc.identifier.pmid33730571


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