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dc.contributor.authorAhouidi, Ambroise
dc.contributor.authorAli, Mozam
dc.contributor.authorAlmagro-Garcia, Jacob
dc.contributor.authorAmambua-Ngwa, Alfred
dc.contributor.authorAmaratunga, Chanaki
dc.contributor.authorAmato, Roberto
dc.contributor.authorAmenga-Etego, Lucas
dc.contributor.authorAndagalu, Ben
dc.contributor.authorAnderson, Tim J C
dc.contributor.authorAndrianaranjaka, Voahangy
dc.contributor.authorApinjoh, Tobias
dc.contributor.authorAriani, Cristina
dc.contributor.authorAshley, Elizabeth A
dc.contributor.authorAuburn, Sarah
dc.contributor.authorAwandare, Gordon
dc.contributor.authorBa, Hampate
dc.contributor.authorBaraka, Vito
dc.contributor.authorBarry, Alyssa E
dc.contributor.authorBejon, Philip
dc.contributor.authorBertin, Gwladys I
dc.contributor.authorBoni, Maciej F
dc.contributor.authorBorrmann, Steffen
dc.contributor.authorBousema, Teun
dc.contributor.authorBranch, Oralee
dc.contributor.authorBull, Peter C
dc.contributor.authorBusby, George B J
dc.contributor.authorChookajorn, Thanat
dc.contributor.authorChotivanich, Kesinee
dc.contributor.authorClaessens, Antoine
dc.contributor.authorConway, David
dc.contributor.authorCraig, Alister
dc.contributor.authorD'Alessandro, Umberto
dc.contributor.authorDama, Souleymane
dc.contributor.authorDay, Nicholas Pj
dc.contributor.authorDenis, Brigitte
dc.contributor.authorDiakite, Mahamadou
dc.contributor.authorDjimdé, Abdoulaye
dc.contributor.authorDolecek, Christiane
dc.contributor.authorDondorp, Arjen M
dc.contributor.authorDrakeley, Chris
dc.contributor.authorDrury, Eleanor
dc.contributor.authorDuffy, Patrick
dc.contributor.authorEcheverry, Diego F
dc.contributor.authorEgwang, Thomas G
dc.contributor.authorErko, Berhanu
dc.contributor.authorFairhurst, Rick M
dc.contributor.authorFaiz, Abdul
dc.contributor.authorFanello, Caterina A
dc.contributor.authorFukuda, Mark M
dc.contributor.authorGamboa, Dionicia
dc.contributor.authorGhansah, Anita
dc.contributor.authorGolassa, Lemu
dc.contributor.authorGoncalves, Sonia
dc.contributor.authorHamilton, William L
dc.contributor.authorHarrison, G L Abby
dc.contributor.authorHart, Lee
dc.contributor.authorHenrichs, Christa
dc.contributor.authorHien, Tran Tinh
dc.contributor.authorHill, Catherine A
dc.contributor.authorHodgson, Abraham
dc.contributor.authorHubbart, Christina
dc.contributor.authorImwong, Mallika
dc.contributor.authorIshengoma, Deus S
dc.contributor.authorJackson, Scott A
dc.contributor.authorJacob, Chris G
dc.contributor.authorJeffery, Ben
dc.contributor.authorJeffreys, Anna E
dc.contributor.authorJohnson, Kimberly J
dc.contributor.authorJyothi, Dushyanth
dc.contributor.authorKamaliddin, Claire
dc.contributor.authorKamau, Edwin
dc.contributor.authorKekre, Mihir
dc.contributor.authorKluczynski, Krzysztof
dc.contributor.authorKochakarn, Theerarat
dc.contributor.authorKonaté, Abibatou
dc.contributor.authorKwiatkowski, Dominic P
dc.contributor.authorKyaw, Myat Phone
dc.contributor.authorLim, Pharath
dc.contributor.authorLon, Chanthap
dc.contributor.authorLoua, Kovana M
dc.contributor.authorMaïga-Ascofaré, Oumou
dc.contributor.authorMalangone, Cinzia
dc.contributor.authorManske, Magnus
dc.contributor.authorMarfurt, Jutta
dc.contributor.authorMarsh, Kevin
dc.contributor.authorMayxay, Mayfong
dc.contributor.authorMiles, Alistair
dc.contributor.authorMiotto, Olivo
dc.contributor.authorMobegi, Victor
dc.contributor.authorMokuolu, Olugbenga A
dc.contributor.authorMontgomery, Jacqui
dc.contributor.authorMueller, Ivo
dc.contributor.authorNewton, Paul N
dc.contributor.authorNguyen, Thuy
dc.contributor.authorNguyen, Thuy-Nhien
dc.contributor.authorNoedl, Harald
dc.contributor.authorNosten, Francois
dc.contributor.authorNoviyanti, Rintis
dc.contributor.authorNzila, Alexis
dc.contributor.authorOchola-Oyier, Lynette I
dc.contributor.authorOcholla, Harold
dc.contributor.authorOduro, Abraham
dc.contributor.authorOmedo, Irene
dc.contributor.authorOnyamboko, Marie A
dc.contributor.authorOuedraogo, Jean-Bosco
dc.contributor.authorOyebola, Kolapo
dc.contributor.authorPearson, Richard D
dc.contributor.authorPeshu, Norbert
dc.contributor.authorPhyo, Aung Pyae
dc.contributor.authorPlowe, Chris V
dc.contributor.authorPrice, Ric N
dc.contributor.authorPukrittayakamee, Sasithon
dc.contributor.authorRandrianarivelojosia, Milijaona
dc.contributor.authorRayner, Julian C
dc.contributor.authorRingwald, Pascal
dc.contributor.authorRockett, Kirk A
dc.contributor.authorRowlands, Katherine
dc.contributor.authorRuiz, Lastenia
dc.contributor.authorSaunders, David
dc.contributor.authorShayo, Alex
dc.contributor.authorSiba, Peter
dc.contributor.authorSimpson, Victoria J
dc.contributor.authorStalker, Jim
dc.contributor.authorSu, Xin-Zhuan
dc.contributor.authorSutherland, Colin
dc.contributor.authorTakala-Harrison, Shannon
dc.contributor.authorTavul, Livingstone
dc.contributor.authorThathy, Vandana
dc.contributor.authorTshefu, Antoinette
dc.contributor.authorVerra, Federica
dc.contributor.authorVinetz, Joseph
dc.contributor.authorWellems, Thomas E
dc.contributor.authorWendler, Jason
dc.contributor.authorWhite, Nicholas J
dc.contributor.authorWright, Ian
dc.contributor.authorYavo, William
dc.contributor.authorYe, Htut
dc.date.accessioned2021-04-09T14:54:54Z
dc.date.available2021-04-09T14:54:54Z
dc.date.issued2021-02-24
dc.identifier.urihttp://hdl.handle.net/10713/15134
dc.description.abstractMalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed.  Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.en_US
dc.description.urihttps://doi.org/10.12688/wellcomeopenres.16168.1en_US
dc.language.isoenen_US
dc.publisherWellcome Trusten_US
dc.relation.ispartofWellcome Open Researchen_US
dc.rightsCopyright: © 2021 MalariaGEN et al.en_US
dc.subjectdata resourceen_US
dc.subjectdrug resistanceen_US
dc.subjectevolutionen_US
dc.subjectgenomic epidemiologyen_US
dc.subjectgenomicsen_US
dc.subjectmalariaen_US
dc.subjectplasmodium falciparumen_US
dc.subjectpopulation geneticsen_US
dc.subjectrapid diagnostic test failureen_US
dc.titleAn open dataset of genome variation in 7,000 worldwide samplesen_US
dc.typeArticleen_US
dc.identifier.doi10.12688/wellcomeopenres.16168.1
dc.identifier.pmid33824913
dc.source.volume6
dc.source.beginpage42
dc.source.endpage
dc.source.countryEngland


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