Author
Ahouidi, AmbroiseAli, Mozam
Almagro-Garcia, Jacob
Amambua-Ngwa, Alfred
Amaratunga, Chanaki
Amato, Roberto
Amenga-Etego, Lucas
Andagalu, Ben
Anderson, Tim J C
Andrianaranjaka, Voahangy
Apinjoh, Tobias
Ariani, Cristina
Ashley, Elizabeth A
Auburn, Sarah
Awandare, Gordon
Ba, Hampate
Baraka, Vito
Barry, Alyssa E
Bejon, Philip
Bertin, Gwladys I
Boni, Maciej F
Borrmann, Steffen
Bousema, Teun
Branch, Oralee
Bull, Peter C
Busby, George B J
Chookajorn, Thanat
Chotivanich, Kesinee
Claessens, Antoine
Conway, David
Craig, Alister
D'Alessandro, Umberto
Dama, Souleymane
Day, Nicholas Pj
Denis, Brigitte
Diakite, Mahamadou
Djimdé, Abdoulaye
Dolecek, Christiane
Dondorp, Arjen M
Drakeley, Chris
Drury, Eleanor
Duffy, Patrick
Echeverry, Diego F
Egwang, Thomas G
Erko, Berhanu
Fairhurst, Rick M
Faiz, Abdul
Fanello, Caterina A
Fukuda, Mark M
Gamboa, Dionicia
Ghansah, Anita
Golassa, Lemu
Goncalves, Sonia
Hamilton, William L
Harrison, G L Abby
Hart, Lee
Henrichs, Christa
Hien, Tran Tinh
Hill, Catherine A
Hodgson, Abraham
Hubbart, Christina
Imwong, Mallika
Ishengoma, Deus S
Jackson, Scott A
Jacob, Chris G
Jeffery, Ben
Jeffreys, Anna E
Johnson, Kimberly J
Jyothi, Dushyanth
Kamaliddin, Claire
Kamau, Edwin
Kekre, Mihir
Kluczynski, Krzysztof
Kochakarn, Theerarat
Konaté, Abibatou
Kwiatkowski, Dominic P
Kyaw, Myat Phone
Lim, Pharath
Lon, Chanthap
Loua, Kovana M
Maïga-Ascofaré, Oumou
Malangone, Cinzia
Manske, Magnus
Marfurt, Jutta
Marsh, Kevin
Mayxay, Mayfong
Miles, Alistair
Miotto, Olivo
Mobegi, Victor
Mokuolu, Olugbenga A
Montgomery, Jacqui
Mueller, Ivo
Newton, Paul N
Nguyen, Thuy
Nguyen, Thuy-Nhien
Noedl, Harald
Nosten, Francois
Noviyanti, Rintis
Nzila, Alexis
Ochola-Oyier, Lynette I
Ocholla, Harold
Oduro, Abraham
Omedo, Irene
Onyamboko, Marie A
Ouedraogo, Jean-Bosco
Oyebola, Kolapo
Pearson, Richard D
Peshu, Norbert
Phyo, Aung Pyae
Plowe, Chris V
Price, Ric N
Pukrittayakamee, Sasithon
Randrianarivelojosia, Milijaona
Rayner, Julian C
Ringwald, Pascal
Rockett, Kirk A
Rowlands, Katherine
Ruiz, Lastenia
Saunders, David
Shayo, Alex
Siba, Peter
Simpson, Victoria J
Stalker, Jim
Su, Xin-Zhuan
Sutherland, Colin
Takala-Harrison, Shannon
Tavul, Livingstone
Thathy, Vandana
Tshefu, Antoinette
Verra, Federica
Vinetz, Joseph
Wellems, Thomas E
Wendler, Jason
White, Nicholas J
Wright, Ian
Yavo, William
Ye, Htut
Date
2021-02-24Journal
Wellcome Open ResearchPublisher
Wellcome TrustType
Article
Metadata
Show full item recordAbstract
MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.Rights/Terms
Copyright: © 2021 MalariaGEN et al.Keyword
data resourcedrug resistance
evolution
genomic epidemiology
genomics
malaria
plasmodium falciparum
population genetics
rapid diagnostic test failure
Identifier to cite or link to this item
http://hdl.handle.net/10713/15134ae974a485f413a2113503eed53cd6c53
10.12688/wellcomeopenres.16168.1