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dc.contributor.authorWon, Junyeon
dc.contributor.authorRanadive, Sushant M
dc.contributor.authorCallow, Daniel D
dc.contributor.authorChen, Shuo
dc.contributor.authorSmith, J. Carsonen_US
dc.date.accessioned2021-04-09T11:47:02Z
dc.date.available2021-04-09T11:47:02Z
dc.date.issued2021-03-26
dc.identifier.urihttp://hdl.handle.net/10713/15128
dc.description.abstractBackground: Although there are moderating effects of race on blood pressure (BP) and brain health in older adults, it is currently unknown if these race-related differences in cardiovascular and associated brain function are also present in younger adults. The purpose of this study was to investigate the interaction between race and BP on brain health in younger African (AA) and Caucasian Americans (CA). Methods: We studied 971 younger adults (29.1 ± 3.5 years; 180 AAs and 791 CAs) who volunteered to participate in the Human Connectome Project. Cognitive composite scores, brain volume, and cortical thickness using MRI were cross-sectionally assessed. ANCOVA was used to examine interactions between race and mean arterial pressure (MAP) on cognitive test scores and brain structure. Results: After controlling for age, sex, education, and BMI, there were significant Race × MAP interaction effects on cognitive composite scores and cortical thickness. Among AAs but not CAs, as MAP increased, both global cognitive performance and entorhinal cortex (ERC) thickness decreased. Conclusions: MAP was an important moderator of racial differences in cognitive performance and ERC thickness. Our findings suggest that young AAs may carry a greater hypertension-associated risk for cognitive brain health deficit. Interventions that address early signs of hypertension in AAs are needed to determine if the racial disparities in BP-related brain health in late adulthood can be reduced. © 2021 The Authors.en_US
dc.description.urihttps://doi.org/10.14814/phy2.14819en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofPhysiological Reportsen_US
dc.rights© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.en_US
dc.subjectblood pressureen_US
dc.subjectcognitive functionen_US
dc.subjectcortical thicknessen_US
dc.subjectmean arterial pressureen_US
dc.subjectraceen_US
dc.subjectyounger adultsen_US
dc.titleBlood pressure-related differences in brain health between young African Americans and Caucasian Americansen_US
dc.typeArticleen_US
dc.identifier.doi10.14814/phy2.14819
dc.identifier.pmid33769700
dc.source.volume9
dc.source.issue6
dc.source.beginpagee14819
dc.source.endpage
dc.source.countryUnited States


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