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    Blood pressure-related differences in brain health between young African Americans and Caucasian Americans

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    Author
    Won, Junyeon
    Ranadive, Sushant M
    Callow, Daniel D
    Chen, Shuo
    Smith, J. Carson
    Date
    2021-03-26
    Journal
    Physiological Reports
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.14814/phy2.14819
    Abstract
    Background: Although there are moderating effects of race on blood pressure (BP) and brain health in older adults, it is currently unknown if these race-related differences in cardiovascular and associated brain function are also present in younger adults. The purpose of this study was to investigate the interaction between race and BP on brain health in younger African (AA) and Caucasian Americans (CA). Methods: We studied 971 younger adults (29.1 ± 3.5 years; 180 AAs and 791 CAs) who volunteered to participate in the Human Connectome Project. Cognitive composite scores, brain volume, and cortical thickness using MRI were cross-sectionally assessed. ANCOVA was used to examine interactions between race and mean arterial pressure (MAP) on cognitive test scores and brain structure. Results: After controlling for age, sex, education, and BMI, there were significant Race × MAP interaction effects on cognitive composite scores and cortical thickness. Among AAs but not CAs, as MAP increased, both global cognitive performance and entorhinal cortex (ERC) thickness decreased. Conclusions: MAP was an important moderator of racial differences in cognitive performance and ERC thickness. Our findings suggest that young AAs may carry a greater hypertension-associated risk for cognitive brain health deficit. Interventions that address early signs of hypertension in AAs are needed to determine if the racial disparities in BP-related brain health in late adulthood can be reduced. © 2021 The Authors.
    Rights/Terms
    © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
    Keyword
    blood pressure
    cognitive function
    cortical thickness
    mean arterial pressure
    race
    younger adults
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15128
    ae974a485f413a2113503eed53cd6c53
    10.14814/phy2.14819
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