School-based screening and treatment may reduce P. falciparum transmission
AuthorCohee, Lauren M
Coalson, Jenna E
Seydel, Karl B
Wilson, Mark L
Taylor, Terrie E
Mathanga, Don P
Laufer, Miriam K
MetadataShow full item record
AbstractIn areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact screening-and-treatment of asymptomatic Malawian schoolchildren (n = 364 in the rainy season and 341 in the dry season) had on gametocyte—the parasite stage responsible for human-to-mosquito transmission—carriage. We used concomitant household-based surveys to predict the potential reduction in transmission in the surrounding community. Among 253 students with P. falciparum infections at screening, 179 (71%) had infections containing gametocytes detected by Pfs25 qRT-PCR. 84% of gametocyte-containing infections were detected by malaria rapid diagnostic test. While the gametocyte prevalence remained constant in untreated children, treatment with artemether-lumefantrine reduced the gametocyte prevalence (p < 0.0001) from 51.8 to 9.7% and geometric mean gametocyte density (p = 0.008) from 0.52 to 0.05 gametocytes/microliter. In community surveys, 46% of all gametocyte-containing infections were in school-age children, who comprised only 35% of the population. Based on these estimates six weeks after the intervention, the gametocyte burden in the community could be reduced by 25–55% depending on the season and the measure used to characterize gametocyte carriage. Thus, school-based interventions to treat asymptomatic infections may be a high-yield approach to not only improve the health of schoolchildren, but also decrease malaria transmission.
SponsorsAPC sponsored by UMB HSHSL
Rights/TermsAttribution 4.0 International
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15123
The following license files are associated with this item:
- Creative Commons
- High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi.
- Authors: Coalson JE, Walldorf JA, Cohee LM, Ismail MD, Mathanga D, Cordy RJ, Marti M, Taylor TE, Seydel KB, Laufer MK, Wilson ML
- Issue date: 2016 Nov 4
- Assessment of submicroscopic infections and gametocyte carriage of Plasmodium falciparum during peak malaria transmission season in a community-based cross-sectional survey in western Kenya, 2012.
- Authors: Zhou Z, Mitchell RM, Kariuki S, Odero C, Otieno P, Otieno K, Onyona P, Were V, Wiegand RE, Gimnig JE, Walker ED, Desai M, Shi YP
- Issue date: 2016 Aug 19
- Plasmodium falciparum gametocyte dynamics after pyronaridine-artesunate or artemether-lumefantrine treatment.
- Authors: Roth JM, Sawa P, Omweri G, Osoti V, Makio N, Bradley J, Bousema T, Schallig HDFH, Mens PF
- Issue date: 2018 Jun 4
- Gametocyte clearance in children, from western Kenya, with uncomplicated Plasmodium falciparum malaria after artemether-lumefantrine or dihydroartemisinin-piperaquine treatment.
- Authors: Omondi P, Burugu M, Matoke-Muhia D, Too E, Nambati EA, Chege W, Musyoka KB, Thiongo K, Otinga M, Muregi F, Kimani F
- Issue date: 2019 Dec 4
- Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season.
- Authors: Oduma CO, Ogolla S, Atieli H, Ondigo BN, Lee MC, Githeko AK, Dent AE, Kazura JW, Yan G, Koepfli C
- Issue date: 2021 Jan 9