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    Brachial Flow-Mediated Dilation and Risk of Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

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    Author
    Garg, Parveen K
    Bartz, Traci M
    Burke, Gregory
    Gottdiener, John S
    Herrington, David
    Heckbert, Susan R
    Kizer, Jorge R
    Sotoodehnia, Nona
    Mukamal, Kenneth J
    Date
    2021-03-11
    Journal
    Vascular Health and Risk Management
    Publisher
    Dove Medical Press Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.2147/VHRM.S297720
    Abstract
    Background: Endothelial dysfunction is associated with common risk factors for AF and has been implicated in the pathophysiology of atrial fibrillation (AF) through a variety of mechanisms. We determined the prospective association of brachial flow-mediated dilation (FMD) with incident AF among older adults. Methods: We included 2027 Cardiovascular Health Study participants (mean age=78.3 years, male=39%, Black=17%) who underwent brachial FMD measurement at the 1997 to 1998 clinic visit. Incident AF was ascertained by study electrocardiograms, hospital dis-charge diagnosis coding and Medicare claims data. Cox regression models were used to examine the association between FMD and incident AF. Results: We identified 754 incident of AF cases (37%) over a median follow-up of 11.0 years. After adjusting for age, sex, race, height, weight, cardiovascular disease, cigarette smoking, hypertension, diabetes, kidney function, c-reactive protein, physical activity, alco-hol consumption, and statins, the risk of AF did not differ according to brachial FMD response (4th vs 1st quartile hazard ratio (HR)=1.01, 95% confidence interval (CI): 0.81, 1.26; per FMD unit increment HR=1.01, 95% CI: 0.97, 1.05). Conclusion: We found no relationship between brachial FMD and the risk of developing AF in this elderly cohort. Our findings suggest that the utility of brachial FMD as a risk marker for AF in older individuals is minimal. © 2021 Garg et al.
    Rights/Terms
    © 2021 Garg et al.
    Keyword
    arrhythmia
    atrial fibrillation
    endothelium
    flow-mediated dilation
    subclinical disease
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15089
    ae974a485f413a2113503eed53cd6c53
    10.2147/VHRM.S297720
    Scopus Count
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    UMB Open Access Articles 2021

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