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dc.contributor.authorBroberg, Craig S.
dc.contributor.authorKovacs, Adrienne H.
dc.contributor.authorSadeghi, Soraya
dc.contributor.authorRosenbaum, Marlon S.
dc.contributor.authorLewis, Matthew J.
dc.contributor.authorCarazo, Matthew R.
dc.contributor.authorRodriguez, Fred H.
dc.contributor.authorHalpern, Dan G.
dc.contributor.authorFeinberg, Jodi
dc.contributor.authorGalilea, Francisca Arancibia
dc.contributor.authorBaraona, Fernando
dc.contributor.authorCedars, Ari M.
dc.contributor.authorKo, Jong M.
dc.contributor.authorPorayette, Prashob
dc.contributor.authorMaldonado, Jennifer
dc.contributor.authorSarubbi, Berardo
dc.contributor.authorFusco, Flavia
dc.contributor.authorFrogoudaki, Alexandra A.
dc.contributor.authorNir, Amiram
dc.contributor.authorChaudhry, Anisa
dc.contributor.authorJohn, Anitha S.
dc.contributor.authorKarbassi, Arsha
dc.contributor.authorHoskoppal, Arvind K.
dc.contributor.authorFrischhertz, Benjamin P.
dc.contributor.authorHendrickson, Benjamin
dc.contributor.authorBouma, Berto J.
dc.contributor.authorRodriguez-Monserrate, Carla P.
dc.contributor.authorBroda, Christopher R.
dc.contributor.authorTobler, Daniel
dc.contributor.authorGregg, David
dc.contributor.authorMartinez-Quintana, Efren
dc.contributor.authorYeung, Elizabeth
dc.contributor.authorKrieger, Eric V.
dc.contributor.authorRuperti-Repilado, Francisco J.
dc.contributor.authorGiannakoulas, George
dc.contributor.authorLui, George K.
dc.contributor.authorEphrem, Georges
dc.contributor.authorSingh, Harsimran S.
dc.contributor.authorAlmeneisi, Hassan MK
dc.contributor.authorBartlett, Heather L.
dc.contributor.authorLindsay, Ian
dc.contributor.authorGrewal, Jasmine
dc.contributor.authorNicolarsen, Jeremy
dc.contributor.authorAraujo, John J.
dc.contributor.authorCramer, Jonathan W.
dc.contributor.authorBouchardy, Judith
dc.contributor.authorAl Najashi, Khalid
dc.contributor.authorRyan, Kristi
dc.contributor.authorAlshawabkeh, Laith
dc.contributor.authorAndrade, Lauren
dc.contributor.authorLadouceur, Magalie
dc.contributor.authorSchwerzmann, Markus
dc.contributor.authorGreutmann, Matthias
dc.contributor.authorMeras, Pablo
dc.contributor.authorFerrero, Paolo
dc.contributor.authorDehghani, Payam
dc.contributor.authorTung, Poyee P.
dc.contributor.authorGarcia-Orta, Rocio
dc.contributor.authorTompkins, Rose O.
dc.contributor.authorGendi, Salwa M.
dc.contributor.authorCohen, Scott
dc.contributor.authorKlewer, Scott
dc.contributor.authorHascoet, Sebastien
dc.contributor.authorMohammadzadeh, Shabnam
dc.contributor.authorUpadhyay, Shailendra
dc.contributor.authorFisher, Stacy D.
dc.contributor.authorCook, Stephen
dc.contributor.authorCotts, Timothy B.
dc.contributor.authorAboulhosn, Jamil A.
dc.date.accessioned2021-04-05T19:25:05Z
dc.date.available2021-04-05T19:25:05Z
dc.date.issued2021-04-06
dc.identifier.urihttp://hdl.handle.net/10713/15088
dc.description.abstractBackground: Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. Objectives: This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Methods: Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. Results: From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. Conclusions: COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity.en_US
dc.description.sponsorshipOregon Health and Science Universityen_US
dc.description.urihttps://doi.org/10.1016/j.jacc.2021.02.023en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subjectadult congenital heart diseaseen_US
dc.subjectcoronavirusen_US
dc.subjectCOVID-19en_US
dc.subjecthospitalizationen_US
dc.titleCOVID-19 in Adults With Congenital Heart Diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jacc.2021.02.023
dc.source.volume77
dc.source.issue13
dc.source.beginpage1644
dc.source.endpage1655


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