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dc.contributor.authorZhou, Shiwei
dc.contributor.authorZeng, Sujuan
dc.contributor.authorShu, Yan
dc.date.accessioned2021-03-16T13:39:45Z
dc.date.available2021-03-16T13:39:45Z
dc.date.issued2021-02-17
dc.identifier.urihttp://hdl.handle.net/10713/14974
dc.description.abstractThe interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.en_US
dc.description.urihttps://doi.org/10.3389/fphar.2021.628705en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Pharmacologyen_US
dc.rightsCopyright © 2021 Zhou, Zeng and Shu.en_US
dc.subjectOCT1en_US
dc.subjectdrug-drug interactionen_US
dc.subjectinhibitoren_US
dc.subjectorganic cation transportersen_US
dc.subjectsubstrateen_US
dc.titleDrug-Drug Interactions at Organic Cation Transporter 1en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fphar.2021.628705
dc.identifier.pmid33679412
dc.source.volume12
dc.source.beginpage628705
dc.source.endpage
dc.source.countrySwitzerland


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