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    Drug-Drug Interactions at Organic Cation Transporter 1

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    Author
    Zhou, Shiwei
    Zeng, Sujuan
    Shu, Yan
    Date
    2021-02-17
    Journal
    Frontiers in Pharmacology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fphar.2021.628705
    Abstract
    The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
    Rights/Terms
    Copyright © 2021 Zhou, Zeng and Shu.
    Keyword
    OCT1
    drug-drug interaction
    inhibitor
    organic cation transporters
    substrate
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14974
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphar.2021.628705
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