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dc.contributor.authorFonseca, Yudy
dc.contributor.authorTshimanga, Taty
dc.contributor.authorRay, Stephen
dc.contributor.authorMalhotra, Helen
dc.contributor.authorPongo, Jean
dc.contributor.authorBodi Mabiala, Joseph
dc.contributor.authorGushu, Montfort Bernard
dc.contributor.authorPhiri, Tusekile
dc.contributor.authorChikaonda, Bertha Mekiseni
dc.contributor.authorAmbitapio Musungufu, Davin
dc.contributor.authorUchama, Mananu
dc.contributor.authorO'Brien, Nicole Fortier
dc.date.accessioned2021-03-16T13:12:46Z
dc.date.available2021-03-16T13:12:46Z
dc.date.issued2021-02-12
dc.identifier.urihttp://hdl.handle.net/10713/14971
dc.description.abstractIntroduction: Bacterial meningitis (BM) is a global public health concern that results in significant morbidity and mortality. Cerebral arterial narrowing contributes to stroke in BM and may be amenable to intervention. However, it is difficult to diagnose in resource-limited settings where the disease is common. Methods: This was a prospective observational study from September 2015 to December 2019 in sub-Saharan Africa. Children 1 month-18 years of age with neutrophilic pleocytosis or a bacterial pathogen identified in the cerebrospinal fluid were enrolled. Transcranial Doppler ultrasound (TCD) of the middle cerebral arteries was performed daily with the aim to identify flow abnormalities consistent with vascular narrowing. Results: Forty-seven patients were analyzed. The majority had Streptococcus pneumoniae (36%) or Neisseria meningitides (36%) meningitis. Admission TCD was normal in 10 (21%). High flow with a normal pulsatility index (PI) was seen in 20 (43%) and high flow with a low PI was identified in 7 (15%). Ten (21%) had low flow. All children with a normal TCD had a good outcome. Patients with a high-risk TCD flow pattern (high flow/low PI or low flow) were more likely to have a poor outcome (82 vs. 38%, p = 0.001). Conclusions: Abnormal TCD flow patterns were common in children with BM and identified those at high risk of poor neurological outcome.en_US
dc.description.urihttps://doi.org/10.3389/fneur.2020.558857en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.rightsCopyright © 2021 Fonseca, Tshimanga, Ray, Malhotra, Pongo, Bodi Mabiala, Gushu, Phiri, Chikaonda, Ambitapio Musungufu, Uchama and O'Brien.en_US
dc.subjectbacterialen_US
dc.subjectmeningitisen_US
dc.subjectneurovascularen_US
dc.subjectpediatricsen_US
dc.subjecttranscranial Doppler ultrasounden_US
dc.titleTranscranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitisen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fneur.2020.558857
dc.identifier.pmid33643174
dc.source.volume11
dc.source.beginpage558857
dc.source.endpage
dc.source.countrySwitzerland


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