Development and deployment of COVID-19 vaccines for those most vulnerable

Koff, Wayne C; Schenkelberg, Theodore; Williams, Tere; Baric, Ralph S; McDermott, Adrian; Cameron, Cheryl M; Cameron, Mark J; Friemann, Matthew B; Neumann, Gabriele; Kawaoka, Yoshihiro; Kelvin, Alyson A; Ross, Ted M; Schultz-Cherry, Stacey; Mastro, Timothy D; Priddy, Frances H; Moore, Kristine A; Ostrowsky, Julia T; Osterholm, Michael T; Goudsmit, Jaap

Date

2021-02-03

Journal

Science Translational Medicine

Publisher

American Association for the Advancement of Science

Type

Article

Metadata

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See at

https://doi.org/10.1126/scitranslmed.abd1525

Abstract

Development of safe and effective COVID-19 vaccines is a global priority and the best hope for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been developed and shown to be efficacious and are already being deployed worldwide. Yet, many challenges remain. Immune senescence and comorbidities in aging populations and immune dysregulation in populations living in low-resource settings may impede vaccine effectiveness. Distribution of vaccines among these populations where vaccine access is historically low remains challenging. In this Review, we address these challenges and provide strategies for ensuring that vaccines are developed and deployed for those most vulnerable. Copyright © 2021 The Authors.

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