Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
AuthorPolanka, Brittanny M
So-Armah, Kaku A
Freiberg, Matthew S
Gupta, Samir K
Zapolski, Tamika C B
Hirsh, Adam T
Bedimo, Roger J
Budoff, Matthew J
Butt, Adeel A
Chang, Chung-Chou H
Gottlieb, Stephen S
Marconi, Vincent C
Womack, Julie A
Stewart, Jesse C
PublisherPublic Library of Science
MetadataShow full item record
AbstractBackground Insomnia may be a risk factor for cardiovascular disease in HIV (HIV-CVD); however, mechanisms have yet to be elucidated. Methods We examined cross-sectional associations of insomnia symptoms with biological mechanisms of HIV-CVD (immune activation, systemic inflammation, and coagulation) among 1,542 people with HIV from the Veterans Aging Cohort Study (VACS) Biomarker Cohort. Past-month insomnia symptoms were assessed by the item, "Difficulty falling or staying asleep?,"with the following response options: "I do not have this symptom"or "I have this symptom and. . .""it doesn't bother me,""it bothers me a little,""it bothers me,""it bothers me a lot."Circulating levels of the monocyte activation marker soluble CD14 (sCD14), inflammatory marker interleukin-6 (IL-6), and coagulation marker D-dimer were determined from blood specimens. Demographic- and fully-adjusted (CVD risk factors, potential confounders, HIV-related factors) regression models were constructed, with log-transformed biomarker variables as the outcomes. We present the exponentiated regression coefficient (exp[b]) and its 95% confidence interval (CI). Results We observed no significant associations between insomnia symptoms and sCD14 or IL-6. For D-dimer, veterans in the "Bothers a Lot"group had, on average, 17% higher D-dimer than veterans in the "No Difficulty Falling or Staying Asleep"group in the demographicadjusted model (exp[b] = 1.17, 95%CI = 1.01-1.37, p = .04). This association was nonsignificant in the fully-adjusted model (exp[b] = 1.09, 95%CI = 0.94-1.26, p = .27). Conclusion We observed little evidence of relationships between insomnia symptoms and markers of biological mechanisms of HIV-CVD. Other mechanisms may be responsible for the insomnia- CVD relationship in HIV; however, future studies with comprehensive assessments of insomnia symptoms are warranted. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Sleep Initiation and Maintenace Disorders--complications
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14843
- Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study.
- Authors: Polanka BM, Kundu S, So-Armah KA, Freiberg MS, Gupta SK, Bedimo RJ, Budoff MJ, Butt AA, Chang CH, Gottlieb SS, Marconi VC, Womack JA, Stewart JC
- Issue date: 2019 May 1
- Associations of Total, Cognitive/Affective, and Somatic Depressive Symptoms and Antidepressant Use With Cardiovascular Disease-Relevant Biomarkers in HIV: Veterans Aging Cohort Study.
- Authors: Stewart JC, Polanka BM, So-Armah KA, White JR, Gupta SK, Kundu S, Chang CH, Freiberg MS
- Issue date: 2020 Jun
- HIV status, burden of comorbid disease, and biomarkers of inflammation, altered coagulation, and monocyte activation.
- Authors: Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M
- Issue date: 2012 Jul
- HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer.
- Authors: Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V 3rd, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS
- Issue date: 2017 Aug 15
- Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?
- Authors: So-Armah KA, Tate JP, Chang CH, Butt AA, Gerschenson M, Gibert CL, Leaf D, Rimland D, Rodriguez-Barradas MC, Budoff MJ, Samet JH, Kuller LH, Deeks SG, Crothers K, Tracy RP, Crane HM, Sajadi MM, Tindle HA, Justice AC, Freiberg MS, VACS Project Team.
- Issue date: 2016 Jun 1