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dc.contributor.authorBoltze, Johannes
dc.contributor.authorAronowski, Jaroslaw A
dc.contributor.authorBadaut, Jerome
dc.contributor.authorBuckwalter, Marion S
dc.contributor.authorCaleo, Mateo
dc.contributor.authorChopp, Michael
dc.contributor.authorDave, Kunjan R
dc.contributor.authorDidwischus, Nadine
dc.contributor.authorDijkhuizen, Rick M
dc.contributor.authorDoeppner, Thorsten R
dc.contributor.authorDreier, Jens P
dc.contributor.authorFouad, Karim
dc.contributor.authorGelderblom, Mathias
dc.contributor.authorGertz, Karen
dc.contributor.authorGolubczyk, Dominika
dc.contributor.authorGregson, Barbara A
dc.contributor.authorHamel, Edith
dc.contributor.authorHanley, Daniel F
dc.contributor.authorHärtig, Wolfgang
dc.contributor.authorHummel, Friedhelm C
dc.contributor.authorIkhsan, Maulana
dc.contributor.authorJanowski, Miroslaw
dc.contributor.authorJolkkonen, Jukka
dc.contributor.authorKaruppagounder, Saravanan S
dc.contributor.authorKeep, Richard F
dc.contributor.authorKoerte, Inga K
dc.contributor.authorKokaia, Zaal
dc.contributor.authorLi, Peiying
dc.contributor.authorLiu, Fudong
dc.contributor.authorLizasoain, Ignacio
dc.contributor.authorLudewig, Peter
dc.contributor.authorMetz, Gerlinde A S
dc.contributor.authorMontagne, Axel
dc.contributor.authorObenaus, Andre
dc.contributor.authorPalumbo, Alex
dc.contributor.authorPearl, Monica
dc.contributor.authorPerez-Pinzon, Miguel
dc.contributor.authorPlanas, Anna M
dc.contributor.authorPlesnila, Nikolaus
dc.contributor.authorRaval, Ami P
dc.contributor.authorRueger, Maria A
dc.contributor.authorSansing, Lauren H
dc.contributor.authorSohrabji, Farida
dc.contributor.authorStagg, Charlotte J
dc.contributor.authorStetler, R Anne
dc.contributor.authorStowe, Ann M
dc.contributor.authorSun, Dandan
dc.contributor.authorTaguchi, Akihiko
dc.contributor.authorTanter, Mickael
dc.contributor.authorVay, Sabine U
dc.contributor.authorVemuganti, Raghu
dc.contributor.authorVivien, Denis
dc.contributor.authorWalczak, Piotr
dc.contributor.authorWang, Jian
dc.contributor.authorXiong, Ye
dc.contributor.authorZille, Marietta
dc.date.accessioned2021-03-04T18:36:51Z
dc.date.available2021-03-04T18:36:51Z
dc.date.issued2021-01-28
dc.identifier.urihttp://hdl.handle.net/10713/14816
dc.description.abstractThe past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress. © Copyright © 2021 The Authors.en_US
dc.description.urihttps://doi.org/10.3389/fnagi.2021.623751en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Aging Neuroscienceen_US
dc.rightsCopyright © 2021 Boltze, Aronowski, Badaut, Buckwalter, Caleo, Chopp, Dave, Didwischus, Dijkhuizen, Doeppner, Dreier, Fouad, Gelderblom, Gertz, Golubczyk, Gregson, Hamel, Hanley, Härtig, Hummel, Ikhsan, Janowski, Jolkkonen, Karuppagounder, Keep, Koerte, Kokaia, Li, Liu, Lizasoain, Ludewig, Metz, Montagne, Obenaus, Palumbo, Pearl, Perez-Pinzon, Planas, Plesnila, Raval, Rueger, Sansing, Sohrabji, Stagg, Stetler, Stowe, Sun, Taguchi, Tanter, Vay, Vemuganti, Vivien, Walczak, Wang, Xiong and Zille.en_US
dc.subjectcell therapiesen_US
dc.subjectdementiaen_US
dc.subjectexperimental therapyen_US
dc.subjecthemorrhageen_US
dc.subjectneuroprotectionen_US
dc.subjectneurorehabilitationen_US
dc.subjectstrokeen_US
dc.subjecttranslational researchen_US
dc.titleNew Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseasesen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fnagi.2021.623751
dc.identifier.pmid33584250
dc.source.volume13
dc.source.beginpage623751
dc.source.endpage
dc.source.countrySwitzerland


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