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dc.contributor.authorNachega, Jean B.
dc.contributor.authorSam-Agudu, Nadia A.
dc.contributor.authorBudhram, Samantha
dc.contributor.authorTaha, Taha E.
dc.contributor.authorVannevel, Valerie
dc.contributor.authorSomapillay, Priya
dc.contributor.authorIshoso, Daniel Katuashi
dc.contributor.authorPipo, Michel Tshiasuma
dc.contributor.authorNswe, Christian Bongo Pasi
dc.contributor.authorDitekemena, John
dc.contributor.authorAyele, Birhanu T.
dc.contributor.authorMachekano, Rhoderick N.
dc.contributor.authorGachuno, Onesmus W.
dc.contributor.authorKinuthia, John
dc.contributor.authorMwongeli, Nancy
dc.contributor.authorSekikubo, Musa
dc.contributor.authorMusoke, Philippa
dc.contributor.authorAgbeno, Evans Kofi
dc.contributor.authorUmar, Lawal W.
dc.contributor.authorNtakwinja, Mukanire
dc.contributor.authorMukwege, Denis M.
dc.contributor.authorSmith, Emily R.
dc.contributor.authorMills, Eduard J.
dc.contributor.authorOtshudiema, John Otokoye
dc.contributor.authorMbala-Kingebeni, Placide
dc.contributor.authorKayembe, Jean Marie N.
dc.contributor.authorLandu, Don Jethro Mavungu
dc.contributor.authorTamfum, Jean Jacques Muyembe
dc.contributor.authorZumla, Alimuddin
dc.contributor.authorLangenegger, Eduard J.
dc.contributor.authorMofenson, Lynne M.
dc.date.accessioned2021-03-03T17:38:08Z
dc.date.available2021-03-03T17:38:08Z
dc.date.issued2021-02-01
dc.identifier.urihttp://hdl.handle.net/10713/14793
dc.description.abstractIn the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health's COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa.en_US
dc.description.sponsorshipNational Institute of Child Health and Human Developmenten_US
dc.description.urihttps://doi.org/10.4269/ajtmh.20-1553en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygieneen_US
dc.subject.meshCOVID-19en_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshPregnancyen_US
dc.subject.meshSARS-CoV-2en_US
dc.subject.meshAfricaen_US
dc.titleEffect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in Africa: An AFREhealth call for evidence through multicountry research collaborationen_US
dc.typeArticleen_US
dc.identifier.doi10.4269/ajtmh.20-1553
dc.identifier.pmid33372651
dc.source.volume104
dc.source.issue2
dc.source.beginpage461
dc.source.endpage465


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