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    Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in Africa: An AFREhealth call for evidence through multicountry research collaboration

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    Author
    Nachega, Jean B.
    Sam-Agudu, Nadia A.
    Budhram, Samantha
    Taha, Taha E.
    Vannevel, Valerie
    Somapillay, Priya
    Ishoso, Daniel Katuashi
    Pipo, Michel Tshiasuma
    Nswe, Christian Bongo Pasi
    Ditekemena, John
    Ayele, Birhanu T.
    Machekano, Rhoderick N.
    Gachuno, Onesmus W.
    Kinuthia, John
    Mwongeli, Nancy
    Sekikubo, Musa
    Musoke, Philippa
    Agbeno, Evans Kofi
    Umar, Lawal W.
    Ntakwinja, Mukanire
    Mukwege, Denis M.
    Smith, Emily R.
    Mills, Eduard J.
    Otshudiema, John Otokoye
    Mbala-Kingebeni, Placide
    Kayembe, Jean Marie N.
    Landu, Don Jethro Mavungu
    Tamfum, Jean Jacques Muyembe
    Zumla, Alimuddin
    Langenegger, Eduard J.
    Mofenson, Lynne M.
    Show allShow less

    Date
    2021-02-01
    Journal
    American Journal of Tropical Medicine and Hygiene
    Publisher
    American Society of Tropical Medicine and Hygiene
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.4269/ajtmh.20-1553
    Abstract
    In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health's COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa.
    Sponsors
    National Institute of Child Health and Human Development
    Keyword
    COVID-19
    Infant, Newborn
    Pregnancy
    SARS-CoV-2
    Africa
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14793
    ae974a485f413a2113503eed53cd6c53
    10.4269/ajtmh.20-1553
    Scopus Count
    Collections
    UMB Open Access Articles 2021
    UMB Coronavirus Publications

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