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dc.contributor.authorKhanam, Arshi
dc.contributor.authorAyithan, Natarajan
dc.contributor.authorTang, Lydia
dc.contributor.authorPoonia, Bhawna
dc.contributor.authorKottilil, Shyam
dc.date.accessioned2021-02-25T15:56:51Z
dc.date.available2021-02-25T15:56:51Z
dc.date.issued2021-01-28
dc.identifier.urihttp://hdl.handle.net/10713/14757
dc.description.abstractChronic Hepatitis B (CHB) affects over 350 million people worldwide. Current treatment does result in reduced complications; however, a cure (development of antibodies to the S antigen) is not achieved, requiring life-long therapy. Humoral responses contribute to viral elimination by secreting neutralizing antibodies; though, effective induction of humoral immunity require CD4T cell differentiation into T follicular helper (TFH) cells that support B cell response through interleukin-21 (IL-21). In CHB, mechanism of TFH-B interactions is seldom described. During CHB, TFH cells are defective in producing IL-21 in response to hepatitis B surface antigen (HBsAg). However, regardless of low IL-21, TFH cells efficiently support B cell responses by producing interleukin-27 (IL-27), which directs the formation of plasmablasts and plasma cells from memory and naïve B cells by enhancing B lymphocyte-induced maturation protein-1. IL-27 not only improved total antibody production but HBsAg-specific IgG and IgM secretion that are essential for viral clearance. Importantly, IL-27+TFH cells were significantly associated with HBV DNA reduction. Therefore, these findings imply a novel mechanism of TFH mediated B cell help in CHB and suggest that IL-27 effectively compensate the function of IL-21 by supporting TFH-B cell function, required for protective antibody response and may contribute to viral clearance by providing potential target for achieving a functional cure.en_US
dc.description.urihttps://doi.org/10.3389/fimmu.2020.599648en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.rightsCopyright © 2021 Khanam, Ayithan, Tang, Poonia and Kottilil.en_US
dc.subjectB cellsen_US
dc.subjectTFH cellsen_US
dc.subjectchronic hepatitis Ben_US
dc.subjectinterleukin-21en_US
dc.subjectinterleukin-27en_US
dc.titleIL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fimmu.2020.599648
dc.identifier.pmid33584666
dc.source.volume11
dc.source.beginpage599648
dc.source.endpage
dc.source.countrySwitzerland


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