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    A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention

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    Author
    Machhi, Jatin
    Shahjin, Farah
    Das, Srijanee
    Patel, Milankumar
    Abdelmoaty, Mai Mohamed
    Cohen, Jacob D
    Singh, Preet Amol
    Baldi, Ashish
    Bajwa, Neha
    Kumar, Raj
    Vora, Lalit K
    Patel, Tapan A
    Oleynikov, Maxim D
    Soni, Dhruvkumar
    Yeapuri, Pravin
    Mukadam, Insiya
    Chakraborty, Rajashree
    Saksena, Caroline G
    Herskovitz, Jonathan
    Hasan, Mahmudul
    Oupicky, David
    Das, Suvarthi
    Donnelly, Ryan F
    Hettie, Kenneth S
    Chang, Linda
    Gendelman, Howard E
    Kevadiya, Bhavesh D
    Show allShow less

    Date
    2021-02-05
    Journal
    Journal of NeuroImmune Pharmacology
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s11481-020-09981-0
    Abstract
    Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease. Interest in EVs as putative vaccines or drug delivery vehicles are substantial. The vesicles have properties of receptors nanoassembly on their surface. EVs can interact with specific immunocytes that include antigen presenting cells (dendritic cells and other mononuclear phagocytes) to elicit immune responses or affect tissue and cellular homeostasis or disease. Due to potential advantages like biocompatibility, biodegradation and efficient immune activation, EVs have gained attraction for the development of treatment or a vaccine system against the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. In this review efforts to use EVs to contain SARS CoV-2 and affect the current viral pandemic are discussed. An emphasis is made on mesenchymal stem cell derived EVs’ as a vaccine candidate delivery system. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s)
    Keyword
    Coronavirus disease 2019 (COVID-19)
    Extracellular vesicles (EVs)
    Mesenchymal stem cells (MSCs)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14743
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11481-020-09981-0
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles 2021

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