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dc.contributor.authorSpector, Anna M.
dc.contributor.authorPostolache, Teodor T.
dc.contributor.authorAkram, Faisal
dc.contributor.authorScott, Alison J.
dc.contributor.authorWadhawan, Abhishek
dc.contributor.authorReynolds, Mark A.
dc.date.accessioned2021-02-22T17:41:20Z
dc.date.available2021-02-22T17:41:20Z
dc.date.issued2020-08-2020
dc.identifier.urihttp://hdl.handle.net/10713/14742
dc.description.abstractPurpose of Review: This review focuses on recent advances in our understanding of the interactions between psychological stress, the immune system, and periodontitis, including the dynamic role of host stress responses in altering immune function, altering the oral microbiome and biofilm formation, and promoting local and systemic disease progression. Recent Findings: Within the context of periodontal health and disease, stress leads to an impairment of effective antimicrobial defense, shifts in oral microbiome profiles toward more pathogenic gene expression and taxa composition, increased translocation, and biofilm formation. The link between stress and periodontitis is multiform and includes hypothalamic–pituitary–adrenal (HPA) axis and catecholamine activation, production of immune mediators of inflammation and, clinically, syndromes of depression, bipolar disorder, anxiety disorders, and sleep-wake disorders. Summary: Psychological stress appears to be an important modifiable risk factor for the development and progression of periodontitis and other periodontal diseases. © 2020, The Author(s).en_US
dc.description.urihttps://doi.org/10.1007/s40496-020-00282-2en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.relation.ispartofCurrent Oral Health Reportsen_US
dc.subjectBiofilmen_US
dc.subjectInflammationen_US
dc.subjectMicrobiomeen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectSleepen_US
dc.subjectStressen_US
dc.titlePsychological Stress: A Predisposing and Exacerbating Factor in Periodontitisen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s40496-020-00282-2
dc.source.volume7
dc.source.issue3
dc.source.beginpage208
dc.source.endpage215


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