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    Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters.

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    Author
    Popovici, Jean
    Tebben, Kieran
    Witkowski, Benoit
    Serre, David
    Date
    2021-01-24
    Journal
    International Journal for Parasitology. Drugs and Drug Resistance
    Publisher
    Elsevier Ltd.
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1016/j.ijpddr.2020.12.004
    Abstract
    Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. All drugs used clinically for killing hypnozoites are 8-aminoquinolines and among them, primaquine has been at the forefront of P. vivax case management for decades. We discuss here the possible factors that could lead to the emergence and selection of P. vivax primaquine resistant parasites and emphasize on how a better understanding of the mechanisms underlying primaquine treatment and hypnozoite biology is needed to prevent this catastrophic scenario from happening. © 2021 The Authors
    Rights/Terms
    Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
    Keyword
    Primaquine
    Plasmodium vivax
    8-aminoquinoline
    Antiprotozoal Agents
    Parasites
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14730
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijpddr.2020.12.004
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