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    Genomic Epidemiology of Antimalarial Drug Resistance in in Southern China.

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    Author
    Huang, Fang
    Jacob, Christopher G
    Takala-Harrison, Shannon
    Adams, Matthew
    Yang, Heng-Lin
    Liu, Hui
    Xia, Zhi-Gui
    Zhou, Shui-Sen
    Tang, Lin-Hua
    Plowe, Christopher V
    Date
    2021-01-08
    Journal
    Frontiers in Cellular and Infection Microbiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fcimb.2020.610985
    Abstract
    Emerging artemisinin resistance in Southeast Asia poses a significant risk to malaria control and eradication goals, including China's plan to eliminate malaria nationwide by 2020. Plasmodium falciparum was endemic in China, especially in Southern China. Parasites from this region have shown decreased susceptibility to artemisinin and delayed parasite clearance after artemisinin treatment. Understanding the genetic basis of artemisinin resistance and identifying specific genetic loci associated with this phenotype is crucial for surveillance and containment of resistance. In this study, parasites were collected from clinical patients from Yunnan province and Hainan island. The parasites were genotyped using a P. falciparum-specific single nucleotide polymorphism (SNP) microarray. The SNP profiles examined included a total of 27 validated and candidate molecular markers of drug resistance. The structure of the parasite population was evaluated by principal component analysis by using the EIGENSOFT program, and ADMIXTURE was used to calculate maximum likelihood estimates for the substructure analysis. Parasites showed a high prevalence of resistance haplotypes of pfdhfr and pfdhps and moderate prevalence of pfcrt. There was no mutation identified on pfmdr1. Candidate SNPs on chromosomes 10, 13, and 14 that were associated with delayed parasite clearance showed a low prevalence of mutants. Parasites from Southern China were clustered and separated from those from Southeast Asia. Parasites from Yunnan province were substructured from parasites from Hainan island. This study provides evidence for a genomic population with drug resistance in Southern China and also illustrates the utility of SNP microarrays for large-scale parasite molecular epidemiology.
    Rights/Terms
    Copyright © 2021 Huang, Jacob, Takala-Harrison, Adams, Yang, Liu, Xia, Zhou, Tang and Plowe.
    Keyword
    Plasmodium falciparum
    Southern China
    antimalarial drugs
    artemisinin resistance
    microarrays
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14704
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcimb.2020.610985
    Scopus Count
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