Show simple item record

dc.contributor.authorTraccis, Francesco
dc.contributor.authorSerra, Valeria
dc.contributor.authorSagheddu, Claudia
dc.contributor.authorCongiu, Mauro
dc.contributor.authorSaba, Pierluigi
dc.contributor.authorGiua, Gabriele
dc.contributor.authorDevoto, Paola
dc.contributor.authorFrau, Roberto
dc.contributor.authorCheer, Joseph Francois
dc.contributor.authorMelis, Miriam
dc.date.accessioned2021-02-16T17:53:43Z
dc.date.available2021-02-16T17:53:43Z
dc.date.issued2021-02-07
dc.identifier.urihttp://hdl.handle.net/10713/14700
dc.description.abstractCannabis use among pregnant women is increasing worldwide along with permissive sociocultural attitudes toward it. Prenatal cannabis exposure (PCE), however, is associated with adverse outcome among offspring, ranging from reduced birth weight to child psychopathology. We have previously shown that male rat offspring prenatally exposed to Δ9-tetrahydrocannabinol (THC), a rat model of PCE, exhibit extensive molecular, cellular, and synaptic changes in dopamine neurons of the ventral tegmental area (VTA), resulting in a susceptible mesolimbic dopamine system associated with a psychotic-like endophenotype. This phenotype only reveals itself upon a single exposure to THC in males but not females. Here, we characterized the impact of PCE on female behaviors and mesolimbic dopamine system function by combining in vivo single-unit extracellular recordings in anesthetized animals and ex vivo patch clamp recordings, along with neurochemical and behavioral analyses. We find that PCE female offspring do not show any spontaneous or THC-induced behavioral disease-relevant phenotypes. The THC-induced increase in dopamine levels in nucleus accumbens was reduced in PCE female offspring, even when VTA dopamine activity in vivo and ex vivo did not differ compared to control. These findings indicate that PCE impacts meso-limbic dopamine function and its related behavioral domains in a sex-dependent manner and war-rant further investigations to decipher the mechanisms determining this sex-related protective effect from intrauterine THC exposure.en_US
dc.description.urihttps://doi.org/10.3390/ijms22041666en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectbehavioren_US
dc.subjectcannabisen_US
dc.subjectdopamineen_US
dc.subjectelectrophysiologyen_US
dc.subjectneurodevelopmenten_US
dc.subjectneuropsychiatric disordersen_US
dc.subjectsexen_US
dc.titlePrenatal THC Does Not Affect Female Mesolimbic Dopaminergic System in Preadolescent Rats.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms22041666
dc.identifier.pmid33562259
dc.source.journaltitleInternational journal of molecular sciences
dc.source.volume22
dc.source.issue4
dc.source.countrySwitzerland


This item appears in the following Collection(s)

Show simple item record