A White Matter Connection of Schizophrenia and Alzheimer's Disease
Author
Kochunov, PeterZavaliangos-Petropulu, Artemis
Jahanshad, Neda
Thompson, Paul M
Ryan, Meghann C
Chiappelli, Joshua
Chen, Shuo
Du, Xiaoming
Hatch, Kathryn
Adhikari, Bhim
Sampath, Hemalatha
Hare, Stephanie
Kvarta, Mark
Goldwaser, Eric
Yang, Fude
Olvera, Rene L
Fox, Peter T
Curran, Joanne E
Blangero, John
Glahn, David C
Tan, Yunlong
Hong, L Elliot
Date
2020-07-18Journal
Schizophrenia BulletinPublisher
Oxford University PressType
Article
Metadata
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Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features. We hypothesized that aging in SZ patients may be associated with the development of cerebral white matter deficit patterns similar to those observed in AD. We identified and replicated aging-related increases in the similarity between white matter deficit patterns in patients with SZ and AD. The white matter "regional vulnerability index" (RVI) for AD was significantly higher in SZ patients compared with healthy controls in both the independent discovery (Cohen's d = 0.44, P = 1·10-5, N = 173 patients/230 control) and replication (Cohen's d = 0.78, P = 9·10-7, N = 122 patients/64 controls) samples. The degree of overlap with the AD deficit pattern was significantly correlated with age in patients (r = .21 and .29, P < .01 in discovery and replication cohorts, respectively) but not in controls. Elevated RVI-AD was significantly associated with cognitive measures in both SZ and AD. Disease and cognitive specificities were also tested in patients with mild cognitive impairment and showed intermediate overlap. SZ and AD have diverse etiologies and clinical courses; our findings suggest that white matter deficits may represent a key intersecting point for these 2 otherwise distinct diseases. Identifying mechanisms underlying this white matter deficit pattern may yield preventative and treatment targets for cognitive deficits in both SZ and AD patients.Rights/Terms
© The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.Identifier to cite or link to this item
http://hdl.handle.net/10713/14682ae974a485f413a2113503eed53cd6c53
10.1093/schbul/sbaa078
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