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    A White Matter Connection of Schizophrenia and Alzheimer's Disease

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    Author
    Kochunov, Peter
    Zavaliangos-Petropulu, Artemis
    Jahanshad, Neda
    Thompson, Paul M
    Ryan, Meghann C
    Chiappelli, Joshua
    Chen, Shuo
    Du, Xiaoming
    Hatch, Kathryn
    Adhikari, Bhim
    Sampath, Hemalatha
    Hare, Stephanie
    Kvarta, Mark
    Goldwaser, Eric
    Yang, Fude
    Olvera, Rene L
    Fox, Peter T
    Curran, Joanne E
    Blangero, John
    Glahn, David C
    Tan, Yunlong
    Hong, L Elliot
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    Date
    2020-07-18
    Journal
    Schizophrenia Bulletin
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/schbul/sbaa078
    Abstract
    Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features. We hypothesized that aging in SZ patients may be associated with the development of cerebral white matter deficit patterns similar to those observed in AD. We identified and replicated aging-related increases in the similarity between white matter deficit patterns in patients with SZ and AD. The white matter "regional vulnerability index" (RVI) for AD was significantly higher in SZ patients compared with healthy controls in both the independent discovery (Cohen's d = 0.44, P = 1·10-5, N = 173 patients/230 control) and replication (Cohen's d = 0.78, P = 9·10-7, N = 122 patients/64 controls) samples. The degree of overlap with the AD deficit pattern was significantly correlated with age in patients (r = .21 and .29, P < .01 in discovery and replication cohorts, respectively) but not in controls. Elevated RVI-AD was significantly associated with cognitive measures in both SZ and AD. Disease and cognitive specificities were also tested in patients with mild cognitive impairment and showed intermediate overlap. SZ and AD have diverse etiologies and clinical courses; our findings suggest that white matter deficits may represent a key intersecting point for these 2 otherwise distinct diseases. Identifying mechanisms underlying this white matter deficit pattern may yield preventative and treatment targets for cognitive deficits in both SZ and AD patients.
    Rights/Terms
    © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
    Keyword
    Alzheimer’s disease
    dementia
    schizophrenia
    white matter deficit pattern
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14682
    ae974a485f413a2113503eed53cd6c53
    10.1093/schbul/sbaa078
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