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dc.contributor.authorUddin, Olivia
dc.contributor.authorAnderson, Michael
dc.contributor.authorSmith, Jesse
dc.contributor.authorMasri, Radi
dc.contributor.authorKeller, Asaf
dc.date.accessioned2021-02-11T20:31:15Z
dc.date.available2021-02-11T20:31:15Z
dc.date.issued2021-01-21
dc.identifier.urihttp://hdl.handle.net/10713/14680
dc.description.abstractMigraines cause significant disability and contribute heavily to healthcare costs. Irritation of the meninges’ outermost layer (the dura mater), and trigeminal ganglion activation contribute to migraine initiation. Maladaptive changes in central pain-processing regions are also important in maintaining pain. The parabrachial complex (PB) is a central region that mediates chronic pain. PB receives diverse sensory information, including a direct input from the trigeminal ganglion. We hypothesized that PB processes inputs from the dura. Using in vivo electrophysiology recordings from single units in anesthetized rats we identified 58 neurons in lateral PB that respond reliably and with short latency to electrical dura stimulation. After injecting tracer into PB, anatomical examination reveals retrogradely labeled cell bodies in the trigeminal ganglion. Neuroanatomical tract-tracing revealed a population of neurons in the trigeminal ganglion that innervate the dura and project directly to PB. These findings indicate that PB is strategically placed to process dura inputs and suggest that it is directly involved in the pathogenesis of migraine headaches.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.description.urihttps://doi.org/10.1016/j.ynpai.2021.100060en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofNeurobiology of Pain (Cambridge, Mass.)en_US
dc.subjectMigraineen_US
dc.subjectPainen_US
dc.subjectParabrachialen_US
dc.subjectTrigeminalen_US
dc.titleParabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ynpai.2021.100060
dc.source.volume9


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