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dc.contributor.authorKawakami, Rika
dc.contributor.authorSakamoto, Atsushi
dc.contributor.authorKawai, Kenji
dc.contributor.authorGianatti, Andrea
dc.contributor.authorPellegrini, Dario
dc.contributor.authorNasr, Ahmed
dc.contributor.authorKutys, Bob
dc.contributor.authorGuo, Liang
dc.contributor.authorCornelissen, Anne
dc.contributor.authorMori, Masayuki
dc.contributor.authorSato, Yu
dc.contributor.authorPescetelli, Irene
dc.contributor.authorBrivio, Matteo
dc.contributor.authorRomero, Maria
dc.contributor.authorGuagliumi, Giulio
dc.contributor.authorVirmani, Renu
dc.contributor.authorFinn, Aloke V
dc.date.accessioned2021-02-11T19:30:50Z
dc.date.available2021-02-11T19:30:50Z
dc.date.issued2021-01-18
dc.identifier.urihttp://hdl.handle.net/10713/14671
dc.description.abstractTo investigate whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)–induced myocarditis constitutes an important mechanism of cardiac injury, a review was conducted of the published data and the authors’ experience was added from autopsy examination of 16 patients dying of SARS-CoV-2 infection. Myocarditis is an uncommon pathologic diagnosis occurring in 4.5% of highly selected cases undergoing autopsy or endomyocardial biopsy. Although polymerase chain reaction–detectable virus could be found in the lungs of most coronavirus disease-2019 (COVID-19)–infected subjects in our own autopsy registry, in only 2 cases was the virus detected in the heart. It should be appreciated that myocardial inflammation alone by macrophages and T cells can be seen in noninfectious deaths and COVID-19 cases, but the extent of each is different, and in neither case do such findings represent clinically relevant myocarditis. Given its extremely low frequency and unclear therapeutic implications, the authors do not advocate use of endomyocardial biopsy to diagnose myocarditis in the setting of COVID-19.en_US
dc.description.urihttps://doi.org/10.1016/j.jacc.2020.11.031en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.rightsCopyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.en_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectcardiovascular diseaseen_US
dc.subjecthearten_US
dc.titlePathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Weeken_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jacc.2020.11.031
dc.identifier.pmid33478655
dc.source.volume77
dc.source.issue3
dc.source.beginpage314
dc.source.endpage325
dc.source.countryUnited States


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