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    Probiotic Use for the Primary Prevention of Clostridioides difficile infection

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    Heil_umaryland_0373N_11209.pdf
    Embargo:
    2021-07-01
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    1.335Mb
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    Author
    Heil, Emily cc
    0000-0002-6644-6684
    Advisor
    Leekha, Surbhi
    Date
    2020
    Type
    dissertation
    
    Metadata
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    Abstract
    Primary prevention of C. difficile infection (CDI) is a priority for hospitals and probiotics have the potential to interfere with colonization and/or infection with C. difficile offering an opportunity to enhance ongoing primary prevention strategies. The overall objective of this study was to evaluate the impact of a hospital-wide computerized clinical decision support system tool to prescribe probiotics to eligible adult patients receiving antibiotics for the primary prevention of CDI. After implementation of the tool, the odds of CDI was 1.41 in eligible patients compared to the pre-intervention time period (aOR 1.41, 95% CI 1.11, 1.79). A propensity score matched analysis showed that patients who received probiotics did not have lower rates of CDI compared to those who did not (OR 1.46, 95% CI 0.87, 2.45). Based on these findings, the use of probiotics for the primary prevention of CDI is not supported.
    Description
    Epidemiology and Preventive Medicine
    University of Maryland, Baltimore
    M.S.
    Keyword
    Clostridioides difficile
    Clostridium Infections
    Decision Support Systems, Clinical
    Inpatients
    Probiotics
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14649
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    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

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