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dc.contributor.authorSantana Ferrer, Luis Fernando*
dc.date.accessioned2012-04-20T19:07:46Z
dc.date.available2012-04-20T19:07:46Z
dc.date.issued1996
dc.identifier.urihttp://hdl.handle.net/10713/1463
dc.descriptionUniversity of Maryland, Baltimore. Physiology. Ph.D. 1996en_US
dc.description.abstractUsing a confocal microscope discrete foci of elevated intracellular Ca2+ concentration ([Ca2+]i), called "Ca2+ sparks", were observed in cardiac, skeletal and vascular smooth muscle cells. In all three muscle types Ca2+ sparks could be attributed to the opening of a single (or a few) ryanodine receptors (RyR). Simultaneous measurement of whole-cell Ca2+ currents (ICa) and Ca2+ sparks in rat ventricular myocytes showed that the probability of Ca2+ spark occurrence (Ps) depends on the square of iCa. Furthermore, it was found that at negative potentials the opening of a single L-type Ca2+ channel can provide enough Ca2+ to activate a single Ca2+ spark by the mechanism of calcium-induced calcium-release (CICR). In skeletal muscle fibers, however, Ca2+ sparks were activated by the voltage-sensor and by CICR. In marked contrast to striated muscle Ca2+ sparks were found to hyperpolarize and relax myogenic cerebral arteries because Ca2+ sparks occupied a small volume of the cell (0.8%), had at low frequency (about 1 Hz), and in occurred close to the sarcolemma were they could activate hyperpolarizing Ca2+-activated potassium (KCa) currents.en_US
dc.language.isoen_USen_US
dc.subjectBiology, Cellen_US
dc.subjectBiology, Animal Physiologyen_US
dc.subjectBiophysics, Generalen_US
dc.subject.meshCalcium Signalingen_US
dc.subject.meshMuscle, Smooth, Vascularen_US
dc.subject.meshMuscle, Skeletalen_US
dc.subject.meshMyocardiumen_US
dc.titleLocal calcium release in muscleen_US
dc.typedissertationen_US
dc.contributor.advisorLederer, W. Jonathan
dc.identifier.ispublishedYes
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