In vitro and in vivo study of the short-term vasomotor response during epileptic seizures
Date
2020-12-07Journal
Brain SciencesPublisher
MDPI AGType
Article
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Epilepsy remains one of the most common brain disorders, and the different types of epilepsy encompass a wide variety of physiological manifestations. Clinical and preclinical findings indicate that cerebral blood flow is usually focally increased at seizure onset, shortly after the beginning of ictal events. Nevertheless, many questions remain about the relationship between vasomotor changes in the epileptic foci and the epileptic behavior of neurons and astrocytes. To study this relationship, we performed a series of in vitro and in vivo experiments using the 4-aminopyridine model of epileptic seizures. It was found that in vitro pathological synchronization of neurons and the depolarization of astrocytes is accompanied by rapid short-term vasoconstriction, while in vivo vasodilation during the seizure prevails. We suggest that vasomotor activity during epileptic seizures is a correlate of the complex, self-sustained response that includes neuronal and astrocytic oscillations, and that underlies the clinical presentation of epilepsy. Copyright 2020 by the authors. Licensee MDPI, Basel, Switzerland.Sponsors
This research was funded by an NIH NIGMS grant (number SC2GM111149) to M.I and by St. Petersburg State University Project Grant (ID 51143531) to A.V.Keyword
4-aminopyridineAstrocytes
Cerebral blood circulation
Epilepsy
Epileptic seizures
Vasoconstriction
Vasodilation
Vasomotor activity
Identifier to cite or link to this item
http://hdl.handle.net/10713/14563ae974a485f413a2113503eed53cd6c53
10.3390/brainsci10120942