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dc.contributor.authorMorales, E.
dc.contributor.authorOlson, M.
dc.contributor.authorIglesias, F.
dc.contributor.authorDahiya, S.
dc.contributor.authorLuetkens, T.
dc.contributor.authorAtanackovic, D.
dc.date.accessioned2021-02-08T20:13:24Z
dc.date.available2021-02-08T20:13:24Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/10713/14542
dc.description.abstractEwing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bone sarcoma in pediatric patients and young adults. Given the dismal overall outcomes and very intensive therapies used, there is an urgent need to explore and develop alternative treatment modalities including immunotherapies. In this article, we provide an overview of ES biology, features of ES tumor microenvironment (TME) and review various tumor-Associated antigens that can be targeted with immune-based approaches including cancer vaccines, monoclonal antibodies, T cell receptor-Transduced T cells, and chimeric antigen receptor T cells. We highlight key reasons for the limited efficacy of various immunotherapeutic approaches for the treatment of ES to date. These factors include absence of human leukocyte antigen class I molecules from the tumor tissue, lack of an ideal surface antigen, and immunosuppressive TME due to the presence of myeloid-derived suppressor cells, F2 fibrocytes, and M2-like macrophages. Lastly, we offer insights into strategies for novel therapeutics development in ES. These strategies include the development of gene-modified T cell receptor T cells against cancer-Testis antigen such as XAGE-1, surface target discovery through detailed profiling of ES surface proteome, and combinatorial approaches. In summary, we provide state-of-The-Art science in ES tumor immunology and immunotherapy, with rationale and recommendations for future therapeutics development.en_US
dc.description.urihttps://doi.org/10.1136/jitc-2020-000653en_US
dc.language.isoen_USen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofJournal for ImmunoTherapy of Cancer
dc.subjectadoptiveen_US
dc.subjectchimeric antigenen_US
dc.subjectimmunotherapyen_US
dc.subjectimmunotherapyen_US
dc.subjectreceptorsen_US
dc.subjectt-lymphocytesen_US
dc.subjectvaccinationen_US
dc.titleRole of immunotherapy in Ewing sarcomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/jitc-2020-000653
dc.identifier.pmid33293354


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