• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Sugar-Coated Killer: Serotype 3 Pneumococcal Disease

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Luck, J.N.
    Tettelin, H.
    Orihuela, C.J.
    Date
    2020-12-23
    Journal
    Frontiers in Cellular and Infection Microbiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fcimb.2020.613287
    Abstract
    Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents entrapment in mucus during colonization, traps water to protect against desiccation, can serve as an energy reserve, and protects the bacterium against complement-mediated opsonization and immune cell phagocytosis. To date, 100 biochemically and serologically distinct capsule types have been identified for S. pneumoniae; 20 to 30 of which have well-defined propensity to cause opportunistic human infection. Among these, serotype 3 is perhaps the most problematic as serotype 3 infections are characterized as having severe clinical manifestations including empyema, bacteremia, cardiotoxicity, and meningitis; consequently, with a fatality rate of 30%–47%. Moreover, serotype 3 resists antibody-mediated clearance despite its inclusion in the current 13-valent conjugate vaccine formulation. This review covers the role of capsule in pneumococcal pathogenesis and the importance of serotype 3 on human disease. We discuss how serotype 3 capsule synthesis and presentation on the bacterial surface is distinct from other serotypes, the biochemical and physiological properties of this capsule type that facilitate its ability to cause disease, and why existing vaccines are unable to confer protection. We conclude with discussion of the clonal properties of serotype 3 and how these have changed since introduction of the 13-valent vaccine in 2000. Copyright Copyright Copyright 2020 Luck, Tettelin and Orihuela.
    Sponsors
    HT and CJO received grant support from NIH grants AI114800 and AI146149.
    Keyword
    capsule production
    invasive pneumococcal disease
    serotype 3
    Streptococcus pneumoniae
    synthase-dependent pathway
    vaccine escape
    wzy-dependent pathway
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14526
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcimb.2020.613287
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Intranasal Immunization with the Commensal <i>Streptococcus mitis</i> Confers Protective Immunity against Pneumococcal Lung Infection.
    • Authors: Shekhar S, Khan R, Schenck K, Petersen FC
    • Issue date: 2019 Mar 15
    • A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large <i>cps</i> Fragment from an Oral Streptococcus.
    • Authors: Ganaie F, Saad JS, McGee L, van Tonder AJ, Bentley SD, Lo SW, Gladstone RA, Turner P, Keenan JD, Breiman RF, Nahm MH
    • Issue date: 2020 May 19
    • Capsule Promotes Intracellular Survival and Vascular Endothelial Cell Translocation during Invasive Pneumococcal Disease.
    • Authors: Brissac T, Martínez E, Kruckow KL, Riegler AN, Ganaie F, Im H, Bakshi S, Arroyo-Diaz NM, Spencer BL, Saad JS, Nahm MH, Orihuela CJ
    • Issue date: 2021 Oct 26
    • Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
    • Authors: Nagai K, Domon H, Maekawa T, Hiyoshi T, Tamura H, Yonezawa D, Habuka R, Saitoh A, Terao Y
    • Issue date: 2019 Jan 3
    • The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies.
    • Authors: Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH
    • Issue date: 2017 Aug
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.