Vaccine-related major cutaneous reaction size correlates with cellular-mediated immune responses after tularaemia immunisation
Author
Salerno-Gonçalves, RosangelaChen, Wilbur H
Mulligan, Mark J
Frey, Sharon E
Stapleton, Jack T
Keitel, Wendy A
Bailey, Jason
Sendra, Eli
Hill, Heather
Johnson, Robert A
Sztein, Marcelo B
Date
2021-01-19Journal
Clinical & Translational ImmunologyPublisher
John Wiley and Sons Inc.Type
Article
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Show full item recordAbstract
Francisella tularensis, the causative agent of tularaemia, is an exceptionally infectious bacterium, potentially fatal for humans if left untreated and with the potential to be developed as a bioweapon. Both natural infection and live-attenuated vaccine strain (LVS) confer good protection against tularaemia. LVS vaccination is traditionally administered by scarification, and the formation of a cutaneous reaction or take at the vaccination site is recognised as a clinical correlate of protection. Although previous studies have suggested that high antibody titres following vaccination might serve as a useful surrogate marker, the immunological correlates of protection remain unknown.Rights/Terms
© 2021 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.Identifier to cite or link to this item
http://hdl.handle.net/10713/14488ae974a485f413a2113503eed53cd6c53
10.1002/cti2.1239
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