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    Vaccine-related major cutaneous reaction size correlates with cellular-mediated immune responses after tularaemia immunisation

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    Author
    Salerno-Gonçalves, Rosangela
    Chen, Wilbur H
    Mulligan, Mark J
    Frey, Sharon E
    Stapleton, Jack T
    Keitel, Wendy A
    Bailey, Jason
    Sendra, Eli
    Hill, Heather
    Johnson, Robert A
    Sztein, Marcelo B
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    Date
    2021-01-19
    Journal
    Clinical & Translational Immunology
    Publisher
    John Wiley and Sons Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/cti2.1239
    Abstract
    Francisella tularensis, the causative agent of tularaemia, is an exceptionally infectious bacterium, potentially fatal for humans if left untreated and with the potential to be developed as a bioweapon. Both natural infection and live-attenuated vaccine strain (LVS) confer good protection against tularaemia. LVS vaccination is traditionally administered by scarification, and the formation of a cutaneous reaction or take at the vaccination site is recognised as a clinical correlate of protection. Although previous studies have suggested that high antibody titres following vaccination might serve as a useful surrogate marker, the immunological correlates of protection remain unknown.
    Rights/Terms
    © 2021 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
    Keyword
    T cells
    human
    take
    tularaemia
    vaccination
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14488
    ae974a485f413a2113503eed53cd6c53
    10.1002/cti2.1239
    Scopus Count
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