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    Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation.

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    Author
    Benedetti, Francesca
    Curreli, Sabrina
    Gallo, Robert C
    Zella, Davide
    Date
    2021-01-11
    Journal
    Cancers
    Publisher
    MDPI AG
    Type
    Article
    Other
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cancers13020241
    Abstract
    A reduced ability to properly repair DNA is linked to a variety of human diseases, which in almost all cases is associated with an increased probability of the development of cellular transformation and cancer. DNA damage, that ultimately can lead to mutations and genomic instability, is due to many factors, such as oxidative stress, metabolic disorders, viral and microbial pathogens, excess cellular proliferation and chemical factors. In this review, we examine the evidence connecting DNA damage and the mechanisms that viruses and bacteria have evolved to hamper the pathways dedicated to maintaining the integrity of genetic information, thus affecting the ability of their hosts to repair the damage(s). Uncovering new links between these important aspects of cancer biology might lead to the development of new targeted therapies in DNA-repair deficient cancers and improving the efficacy of existing therapies. Here we provide a comprehensive summary detailing the major mechanisms that viruses and bacteria associated with cancer employ to interfere with mechanisms of DNA repair. Comparing these mechanisms could ultimately help provide a common framework to better understand how certain microorganisms are involved in cellular transformation. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
    Keyword
    DNA damage
    DNA repair
    bacteria
    carcinogenesis
    cellular pathways
    viruses
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14403
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13020241
    Scopus Count
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