MetadataShow full item record
AbstractB and T cells are key components of the adaptive immune system and coordinate multiple facets of immunity including responses to infection, vaccines, allergens, and the environment. In humans, B- and T-cell immunity has been determined using primarily peripheral blood specimens. Conversely, human tissues have scarcely been studied but they host multiple adaptive immune cells capable of mounting immune responses to pathogens and participate in tissue homeostasis. Mucosal tissues, such as the intestines and respiratory track, are constantly bombarded by foreign antigens and contain tissue-resident memory T (TRM) cells that exhibit superior protective capacity to pathogens. Also, tissue-resident memory B (BRM) cells have been identified in mice but whether humans have a similar population remains to be confirmed. Moreover, the immune system evolves throughout the lifespan of humans and undergoes multiple changes in its immunobiology. Recent studies have shown that age-related changes in tissues are not necessarily reflected in peripheral blood specimens, highlighting the importance of tissue localization and subset delineation as essential determinants of functional B and T cells at different life stages. This review describes our current knowledge of the main B- and T-cell subsets in peripheral blood and tissues across age groups.
tissue-resident memory cells
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14400
- Human T Cell Development, Localization, and Function throughout Life.
- Authors: Kumar BV, Connors TJ, Farber DL
- Issue date: 2018 Feb 20
- Tissue-resident lymphocytes: from adaptive to innate immunity.
- Authors: Sun H, Sun C, Xiao W, Sun R
- Issue date: 2019 Mar
- CD4 T<sub>RM</sub> Cells Following Infection and Immunization: Implications for More Effective Vaccine Design.
- Authors: Wilk MM, Mills KHG
- Issue date: 2018
- Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.
- Authors: Gebhardt T, Palendira U, Tscharke DC, Bedoui S
- Issue date: 2018 May
- Formation and function of tissue-resident memory T cells during viral infection.
- Authors: Shin H
- Issue date: 2018 Feb