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    B and T Cell Immunity in Tissues and Across the Ages.

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    Author
    Booth, Jayaum S
    Toapanta, Franklin R
    Date
    2021-01-06
    Journal
    Vaccines
    Publisher
    MDPI AG
    Type
    Article
    Other
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/vaccines9010024
    Abstract
    B and T cells are key components of the adaptive immune system and coordinate multiple facets of immunity including responses to infection, vaccines, allergens, and the environment. In humans, B- and T-cell immunity has been determined using primarily peripheral blood specimens. Conversely, human tissues have scarcely been studied but they host multiple adaptive immune cells capable of mounting immune responses to pathogens and participate in tissue homeostasis. Mucosal tissues, such as the intestines and respiratory track, are constantly bombarded by foreign antigens and contain tissue-resident memory T (TRM) cells that exhibit superior protective capacity to pathogens. Also, tissue-resident memory B (BRM) cells have been identified in mice but whether humans have a similar population remains to be confirmed. Moreover, the immune system evolves throughout the lifespan of humans and undergoes multiple changes in its immunobiology. Recent studies have shown that age-related changes in tissues are not necessarily reflected in peripheral blood specimens, highlighting the importance of tissue localization and subset delineation as essential determinants of functional B and T cells at different life stages. This review describes our current knowledge of the main B- and T-cell subsets in peripheral blood and tissues across age groups.
    Keyword
    B cells
    T cells
    intestine
    mucosal immunity
    respiratory track
    tissue-resident memory cells
    vaccines
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14400
    ae974a485f413a2113503eed53cd6c53
    10.3390/vaccines9010024
    Scopus Count
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    UMB Open Access Articles 2021

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