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    Reporting regression in primary cutaneous melanoma. Part 1: history, histological criteria and pathogenesis

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    Author
    Cartron, A M
    Aldana, P C
    Khachemoune, A
    Date
    2020-06-29
    Journal
    Clinical and Experimental Dermatology
    Publisher
    Blackwell Publishing
    Type
    Article
    Other
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1111/ced.14328
    Abstract
    Regression is an important histopathological parameter reported for the diagnosis of primary cutaneous melanoma. Histological regression is defined by The College of American Pathologists as the replacement of tumour cells by lymphocytic inflammation, with attenuation of the epidermis, and nonlaminated dermal fibrosis with inflammatory cells, melanophagocytosis and telangiectasia. Histological regression may be reported as absent versus present and, if present, as complete, partial or segmental. The stages of histological regression are early, intermediate and late, depending on the extent of histological inflammation and fibrosis. Regression occurs when the host’s immune system attacks primary melanocytic tumour cells via tumour-infiltrating lymphocytes, resulting in fibrosis. The immunological mechanisms driving complete, partial and segmental regression may vary. In this first part of this two-part review, we review the history, histological criteria and pathogenesis of regression in primary cutaneous melanoma, while in Part 2 we will review the effect of histological regression on prognosis, evaluation and management.
    Rights/Terms
    © 2020 British Association of Dermatologists.
    Keyword
    histological regression
    Melanoma
    Skin Neoplasms
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14393
    ae974a485f413a2113503eed53cd6c53
    10.1111/ced.14328
    Scopus Count
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    UMB Open Access Articles 2020

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