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dc.contributor.authorLagou, Vasiliki
dc.contributor.authorMägi, Reedik
dc.contributor.authorHottenga, Jouke- Jan
dc.contributor.authorGrallert, Harald
dc.contributor.authorPerry, John R B
dc.contributor.authorBouatia-Naji, Nabila
dc.contributor.authorMarullo, Letizia
dc.contributor.authorRybin, Denis
dc.contributor.authorJansen, Rick
dc.contributor.authorMin, Josine L
dc.contributor.authorDimas, Antigone S
dc.contributor.authorUlrich, Anna
dc.contributor.authorZudina, Liudmila
dc.contributor.authorGådin, Jesper R
dc.contributor.authorJiang, Longda
dc.contributor.authorFaggian, Alessia
dc.contributor.authorBonnefond, Amélie
dc.contributor.authorFadista, Joao
dc.contributor.authorStathopoulou, Maria G
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorWillems, Sara M
dc.contributor.authorNavarro, Pau
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorJackson, Anne U
dc.contributor.authorMontasser, May E
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorBielak, Lawrence F
dc.contributor.authorWebster, Rebecca J
dc.contributor.authorSaxena, Richa
dc.contributor.authorStafford, Jeanette M
dc.contributor.authorPourcain, Beate St
dc.contributor.authorTimpson, Nicholas J
dc.contributor.authorSalo, Perttu
dc.contributor.authorShin, So-Youn
dc.contributor.authorAmin, Najaf
dc.contributor.authorSmith, Albert V
dc.contributor.authorLi, Guo
dc.contributor.authorVerweij, Niek
dc.contributor.authorGoel, Anuj
dc.contributor.authorFord, Ian
dc.contributor.authorJohnson, Paul C D
dc.contributor.authorJohnson, Toby
dc.contributor.authorKapur, Karen
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorStrawbridge, Rona J
dc.contributor.authorRasmussen-Torvik, Laura J
dc.contributor.authorEsko, Tõnu
dc.contributor.authorMihailov, Evelin
dc.contributor.authorFall, Tove
dc.contributor.authorFraser, Ross M
dc.contributor.authorMahajan, Anubha
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorKleber, Marcus E
dc.contributor.authorSilbernagel, Günther
dc.contributor.authorMeyer, Julia
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorGanna, Andrea
dc.contributor.authorSarin, Antti-Pekka
dc.contributor.authorYengo, Loic
dc.contributor.authorShungin, Dmitry
dc.contributor.authorLuan, Jian'an
dc.contributor.authorHorikoshi, Momoko
dc.contributor.authorAn, Ping
dc.contributor.authorSanna, Serena
dc.contributor.authorBoettcher, Yvonne
dc.contributor.authorRayner, N William
dc.contributor.authorNolte, Ilja M
dc.contributor.authorZemunik, Tatijana
dc.contributor.authorIperen, Erik van
dc.contributor.authorKovacs, Peter
dc.contributor.authorHastie, Nicholas D
dc.contributor.authorWild, Sarah H
dc.contributor.authorMcLachlan, Stela
dc.contributor.authorCampbell, Susan
dc.contributor.authorPolasek, Ozren
dc.contributor.authorCarlson, Olga
dc.contributor.authorEgan, Josephine
dc.contributor.authorKiess, Wieland
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLaakso, Markku
dc.contributor.authorDimitriou, Maria
dc.contributor.authorHicks, Andrew A
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorThorand, Barbara
dc.contributor.authorLiu, Yongmei
dc.contributor.authorMiljkovic, Iva
dc.contributor.authorLind, Lars
dc.contributor.authorDoney, Alex
dc.contributor.authorPerola, Markus
dc.contributor.authorHingorani, Aroon
dc.contributor.authorKivimaki, Mika
dc.contributor.authorKumari, Meena
dc.contributor.authorBennett, Amanda J
dc.contributor.authorGroves, Christopher J
dc.contributor.authorHerder, Christian
dc.contributor.authorKoistinen, Heikki A
dc.contributor.authorKinnunen, Leena
dc.contributor.authorFaire, Ulf de
dc.contributor.authorBakker, Stephan J L
dc.contributor.authorUusitupa, Matti
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorJukema, J Wouter
dc.contributor.authorSattar, Naveed
dc.contributor.authorPouta, Anneli
dc.contributor.authorSnieder, Harold
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorPankow, James S
dc.contributor.authorMagnusson, Patrik K
dc.contributor.authorKrus, Ulrika
dc.contributor.authorScapoli, Chiara
dc.contributor.authorde Geus, Eco J C N
dc.contributor.authorBlüher, Matthias
dc.contributor.authorWolffenbuttel, Bruce H R
dc.contributor.authorProvince, Michael A
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorMeigs, James B
dc.contributor.authorHovingh, G Kees
dc.contributor.authorLindström, Jaana
dc.contributor.authorWilson, James F
dc.contributor.authorWright, Alan F
dc.contributor.authorDedoussis, George V
dc.contributor.authorBornstein, Stefan R
dc.contributor.authorSchwarz, Peter E H
dc.contributor.authorTönjes, Anke
dc.contributor.authorWinkelmann, Bernhard R
dc.contributor.authorBoehm, Bernhard O
dc.contributor.authorMärz, Winfried
dc.contributor.authorMetspalu, Andres
dc.contributor.authorPrice, Jackie F
dc.contributor.authorDeloukas, Panos
dc.contributor.authorKörner, Antje
dc.contributor.authorLakka, Timo A
dc.contributor.authorKeinanen-Kiukaanniemi, Sirkka M
dc.contributor.authorSaaristo, Timo E
dc.contributor.authorBergman, Richard N
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorMännistö, Satu
dc.contributor.authorFranks, Paul W
dc.contributor.authorHayward, Caroline
dc.contributor.authorVitart, Veronique
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorVisvikis-Siest, Sophie
dc.contributor.authorBalkau, Beverley
dc.contributor.authorAltshuler, David
dc.contributor.authorRudan, Igor
dc.contributor.authorStumvoll, Michael
dc.contributor.authorCampbell, Harry
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorGieger, Christian
dc.contributor.authorIllig, Thomas
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorBoehnke, Michael
dc.contributor.authorFrayling, Timothy M
dc.contributor.authorShuldiner, Alan R
dc.contributor.authorPeyser, Patricia A
dc.contributor.authorKardia, Sharon L R
dc.contributor.authorPalmer, Lyle J
dc.contributor.authorPenninx, Brenda W
dc.contributor.authorMeneton, Pierre
dc.contributor.authorHarris, Tamara B
dc.contributor.authorNavis, Gerjan
dc.contributor.authorHarst, Pim van der
dc.contributor.authorSmith, George Davey
dc.contributor.authorForouhi, Nita G
dc.contributor.authorLoos, Ruth J F
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorGroop, Leif
dc.contributor.authorTuomi, Tiinamaija
dc.contributor.authorHofman, Albert
dc.contributor.authorMunroe, Patricia B
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorSiscovick, David S
dc.contributor.authorWatkins, Hugh
dc.contributor.authorLecoeur, Cecile
dc.contributor.authorVollenweider, Peter
dc.contributor.authorFranco-Cereceda, Anders
dc.contributor.authorEriksson, Per
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorStefansson, Kari
dc.contributor.authorHamsten, Anders
dc.contributor.authorNicholson, George
dc.contributor.authorKarpe, Fredrik
dc.contributor.authorDermitzakis, Emmanouil T
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorMcCarthy, Mark I
dc.contributor.authorFroguel, Philippe
dc.contributor.authorKaakinen, Marika A
dc.contributor.authorLyssenko, Valeriya
dc.contributor.authorWatanabe, Richard M
dc.contributor.authorIngelsson, Erik
dc.contributor.authorFlorez, Jose C
dc.contributor.authorDupuis, Josée
dc.contributor.authorBarroso, Inês
dc.contributor.authorMorris, Andrew P
dc.contributor.authorProkopenko, Inga
dc.date.accessioned2021-01-20T18:57:24Z
dc.date.available2021-01-20T18:57:24Z
dc.date.issued2021-01-05
dc.identifier.urihttp://hdl.handle.net/10713/14372
dc.descriptionPublisher correction at https://doi.org/10.1038/s41467-021-21276-3. The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently swapped. This has now been corrected in the PDF and HTML versions of the Article. © 2021, The Author(s).
dc.description.abstractDifferences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes. © 2021, The Author(s).en_US
dc.description.urihttps://doi.org/10.1038/s41467-020-19366-9en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-21276-3
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.subject.meshSex Characteristicsen_US
dc.subject.meshGlucoseen_US
dc.subject.meshInsulinen_US
dc.titleSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variabilityen_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.1038/s41467-020-19366-9
dc.identifier.doi10.1038/s41467-021-21276-3
dc.identifier.pmid33402679
dc.source.volume12
dc.source.issue1
dc.source.beginpage24
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryEngland


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