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    Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD

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    Author
    Navaneethan, Sankar D
    Kirwan, John P
    Remer, Erick M
    Schneider, Erika
    Addeman, Bryan
    Arrigain, Susana
    Horwitz, Ed
    Fink, Jeffrey C
    Lash, James P
    McKenzie, Charles A
    Rahman, Mahboob
    Rao, Panduranga S
    Schold, Jesse D
    Shafi, Tariq
    Taliercio, Jonathan J
    Townsend, Raymond R
    Feldman, Harold I
    Show allShow less

    Date
    2020-08-13
    Journal
    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    Publisher
    Elsevier Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1053/j.ajkd.2020.05.028
    Abstract
    Mean age of the study population was 64.3 years; 41% were women, and mean estimated glomerular filtration rate was 53.2±14.6 (SD) mL/min/1.73m2. More than 85% were overweight or obese, and 40% had diabetes. Higher VAT volume, SAT volume, and liver proton density fat fraction were associated with lower levels of total and high-molecular-weight adiponectin, higher levels of leptin and insulin resistance, and lower high-density lipoprotein cholesterol and higher serum triglyceride levels. A slower 400-m walk time was associated only with higher levels of leptin, total adiponectin, plasma IL-6, and TNFR1 and did not modify the associations between fat measures and cardiometabolic risk factors.
    Rights/Terms
    Copyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
    Keyword
    Obesity
    abdominal fat
    adipose tissue
    body mass index (BMI)
    cardiometabolic risk factor
    cardiovascular disease
    chronic kidney disease (CKD)
    fat
    fat distribution
    overweight
    physical function
    renal dysfunction
    subcutaneous fat
    Show allShow less
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14322
    ae974a485f413a2113503eed53cd6c53
    10.1053/j.ajkd.2020.05.028
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    UMB Open Access Articles 2020

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