Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD
AuthorNavaneethan, Sankar D
Kirwan, John P
Remer, Erick M
Fink, Jeffrey C
Lash, James P
McKenzie, Charles A
Rao, Panduranga S
Schold, Jesse D
Taliercio, Jonathan J
Townsend, Raymond R
Feldman, Harold I
JournalAmerican Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
MetadataShow full item record
AbstractMean age of the study population was 64.3 years; 41% were women, and mean estimated glomerular filtration rate was 53.2±14.6 (SD) mL/min/1.73m2. More than 85% were overweight or obese, and 40% had diabetes. Higher VAT volume, SAT volume, and liver proton density fat fraction were associated with lower levels of total and high-molecular-weight adiponectin, higher levels of leptin and insulin resistance, and lower high-density lipoprotein cholesterol and higher serum triglyceride levels. A slower 400-m walk time was associated only with higher levels of leptin, total adiponectin, plasma IL-6, and TNFR1 and did not modify the associations between fat measures and cardiometabolic risk factors.
Rights/TermsCopyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
body mass index (BMI)
cardiometabolic risk factor
chronic kidney disease (CKD)
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14322
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